DIS3 and NTMT1

Data Source:
BioGRID (two hybrid)

		DIS3	NTMT1
Description		DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease	N-terminal Xaa-Pro-Lys N-methyltransferase 1
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Endonuclease Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Methyltransferase Activity Protein Methyltransferase Activity Histone Methyltransferase Activity N-terminal Protein N-methyltransferase Activity
	Biological Process	RRNA Processing RRNA Catabolic Process Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA Regulation Of Catalytic Activity CUT Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	N-terminal Protein Amino Acid Methylation Spindle Organization Chromosome Segregation Histone Methylation N-terminal Peptidyl-alanine Methylation N-terminal Peptidyl-alanine Trimethylation N-terminal Peptidyl-glycine Methylation N-terminal Peptidyl-proline Dimethylation N-terminal Peptidyl-proline Methylation N-terminal Peptidyl-serine Methylation N-terminal Peptidyl-serine Dimethylation N-terminal Peptidyl-serine Trimethylation
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Restless legs syndrome ( 29029846)
Interacting Genes		12 interacting genes: EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MTREX NTMT1 PALS2 ZBTB17	7 interacting genes: APP DDB2 DIS3 GLYR1 HNRNPD IKBKG RCC1
Entrez ID		22894	28989
HPRD ID		06338	10628
Ensembl ID		ENSG00000083520	ENSG00000148335
Uniprot IDs		G3V1J5 Q9Y2L1	A0A024R8E4 Q9BV86 S4R338
PDB IDs		6D6Q 6D6R 6H25	2EX4 5CVD 5CVE 5E1B 5E1D 5E1M 5E1O 5E2A 5E2B 6DTN 6KDQ 6PVA 6PVB 6WH8 6WJ7
Enriched GO Terms of Interacting Partners?
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