PLEKHA6 and PLEKHA5

Data Source:
BioGRID (two hybrid)

		PLEKHA6	PLEKHA5
Description		pleckstrin homology domain containing A6	pleckstrin homology domain containing A5
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GO Annotations	Cellular Component		Nucleoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process		Biological_process Reproductive System Development
Pathways		Synthesis of PIPs at the plasma membrane	Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Palmitoleic acid (16:1n-7) levels ( 23362303) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Prostate cancer ( 23535732) Red blood cell count ( 32888494) Regular attendance at a religious group ( 29970889) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Adult body size ( 32376654) Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Platelet reactivity in response to clopidogrel treatment ( 32472697) Thalamus volume ( 31530798)
Interacting Genes		3 interacting genes: APOE PLEKHA5 UBE2Z	31 interacting genes: ARHGEF9 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX PDZD11 PLEC PLEKHA6 PPP1R13B PROM1 SH3BP5L SOGA1 SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG
Entrez ID		22874	54477
HPRD ID		09685	09684
Ensembl ID		ENSG00000143850	ENSG00000052126
Uniprot IDs		Q9Y2H5	A0A024RAY7 Q9HAU0
PDB IDs		2D9Y 2YRY	2DKP
Enriched GO Terms of Interacting Partners?
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