PLEKHA5 and PROM1

Data Source:
BioGRID (two hybrid)

		PLEKHA5	PROM1
Description		pleckstrin homology domain containing A5	prominin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse	Photoreceptor Outer Segment Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cilium Cell Surface Apical Plasma Membrane Microvillus Membrane Vesicle Photoreceptor Outer Segment Membrane Extracellular Exosome Prominosome
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding Cholesterol Binding Actinin Binding Cadherin Binding
	Biological Process	Biological_process Reproductive System Development	Retina Layer Formation Photoreceptor Cell Maintenance Retina Morphogenesis In Camera-type Eye Camera-type Eye Photoreceptor Cell Differentiation Glomerular Visceral Epithelial Cell Differentiation Glomerular Parietal Epithelial Cell Differentiation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation
Pathways		Synthesis of PIPs at the plasma membrane
Drugs
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD) Stargardt disease (STGD); Fundus flavimaculatus Retinitis pigmentosa (RP)
GWAS		Adult body size ( 32376654) Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Platelet reactivity in response to clopidogrel treatment ( 32472697) Thalamus volume ( 31530798)	Dental caries ( 23064961) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glomerular filtration rate in chronic kidney disease ( 26420894) Intracranial aneurysm ( 29531279) Pulse pressure ( 30224653) Self-rated health ( 20707712) Suicide attempts in depression or bipolar disorder ( 24964207)
Interacting Genes		31 interacting genes: ARHGEF9 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX PDZD11 PLEC PLEKHA6 PPP1R13B PROM1 SH3BP5L SOGA1 SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG	4 interacting genes: HDAC6 PIK3R1 PLEKHA5 SRC
Entrez ID		54477	8842
HPRD ID		09684	05079
Ensembl ID		ENSG00000052126	ENSG00000007062
Uniprot IDs		A0A024RAY7 Q9HAU0	A0A0A0N0M1 O43490
PDB IDs		2DKP
Enriched GO Terms of Interacting Partners?
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