PLEKHA5 and EVPL

Data Source:
BioGRID (two hybrid)

		PLEKHA5	EVPL
Description		pleckstrin homology domain containing A5	envoplakin
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse	Cornified Envelope Cytoplasm Cytosol Intermediate Filament Membrane Desmosome Intermediate Filament Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Structural Molecule Activity Intermediate Filament Binding Cadherin Binding
	Biological Process	Biological_process Reproductive System Development	Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Wound Healing Intermediate Filament Cytoskeleton Organization Cornification
Pathways		Synthesis of PIPs at the plasma membrane	Formation of the cornified envelope
Drugs
Diseases
GWAS		Adult body size ( 32376654) Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Platelet reactivity in response to clopidogrel treatment ( 32472697) Thalamus volume ( 31530798)	Deep white matter hyperintensities ( 32517579) Depressive symptom improvement ( 30468137) L-selectin levels ( 25576479) Metabolite levels ( 23823483) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		31 interacting genes: ARHGEF9 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX PDZD11 PLEC PLEKHA6 PPP1R13B PROM1 SH3BP5L SOGA1 SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG	14 interacting genes: CSTA DSP IVL KRT1 KRT10 KRT2 KRT5 LORICRIN PI3 PLEKHA5 PPL PSORS1C2 SPRR2A SPRR3
Entrez ID		54477	2125
HPRD ID		09684	03352
Ensembl ID		ENSG00000052126	ENSG00000167880
Uniprot IDs		A0A024RAY7 Q9HAU0	B7ZLH8 K7EKI0 Q92817
PDB IDs		2DKP	4QMD
Enriched GO Terms of Interacting Partners?
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