PLEKHA6 and UBE2Z

Data Source:
BioGRID (two hybrid)

		PLEKHA6	UBE2Z
Description		pleckstrin homology domain containing A6	ubiquitin conjugating enzyme E2 Z
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GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process		Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Negative Regulation Of Endopeptidase Activity Protein Ubiquitination Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process
Pathways		Synthesis of PIPs at the plasma membrane	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Palmitoleic acid (16:1n-7) levels ( 23362303) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Prostate cancer ( 23535732) Red blood cell count ( 32888494) Regular attendance at a religious group ( 29970889) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 31562340) Myocardial infarction ( 26343387) Platelet count ( 32888494) Plateletcrit ( 32888494) Type 2 diabetes ( 30054458 29358691)
Interacting Genes		3 interacting genes: APOE PLEKHA5 UBE2Z	39 interacting genes: AK8 BMPR1B CCT3 DZIP3 GORASP2 HLTF HMBOX1 INCA1 LNX2 LPL MDM2 OTUB1 PLEKHA6 PLEKHF2 PPP1CA PRKN RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM3 TRIM46 TRIM65 UBA1 UBA6 UBD
Entrez ID		22874	65264
HPRD ID		09685	08589
Ensembl ID		ENSG00000143850	ENSG00000159202
Uniprot IDs		Q9Y2H5	Q9H832
PDB IDs		2D9Y 2YRY	5A4P
Enriched GO Terms of Interacting Partners?
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