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MTA1 and DYNLL1
Data Source:
HPRD
(in vitro)
MTA1
DYNLL1
Description
metastasis associated 1
dynein light chain LC8-type 1
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Cytosol
Microtubule
NuRD Complex
Intracellular Membrane-bounded Organelle
Kinetochore
Nucleus
Cytoplasm
Mitochondrion
Centrosome
Cytosol
Cytoplasmic Dynein Complex
Microtubule
Plasma Membrane
Cilium
COP9 Signalosome
Membrane
Dynein Complex
Tertiary Granule Membrane
Mitotic Spindle
Ciliary Tip
Ficolin-1-rich Granule Membrane
Axon Cytoplasm
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Repressing Transcription Factor Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Zinc Ion Binding
Histone Deacetylase Binding
Motor Activity
Enzyme Inhibitor Activity
Protein Binding
Protein C-terminus Binding
Enzyme Binding
Protein Domain Specific Binding
Nitric-oxide Synthase Regulator Activity
Identical Protein Binding
Protein-containing Complex Binding
Dynein Intermediate Chain Binding
Dynein Light Intermediate Chain Binding
Scaffold Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Double-strand Break Repair
Signal Transduction
Response To Ionizing Radiation
Histone Deacetylation
Circadian Regulation Of Gene Expression
Regulation Of Gene Expression, Epigenetic
Entrainment Of Circadian Clock By Photoperiod
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Locomotor Rhythm
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Protein Autoubiquitination
G2/M Transition Of Mitotic Cell Cycle
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Apoptotic Process
Spermatid Development
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Macroautophagy
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Substantia Nigra Development
Intraciliary Retrograde Transport
Intraciliary Transport Involved In Cilium Assembly
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Negative Regulation Of Phosphorylation
Negative Regulation Of Catalytic Activity
Neutrophil Degranulation
Motile Cilium Assembly
Negative Regulation Of Nitric Oxide Biosynthetic Process
Cilium Assembly
Ciliary Basal Body-plasma Membrane Docking
Positive Regulation Of Non-motile Cilium Assembly
Positive Regulation Of ATP-dependent Microtubule Motor Activity, Plus-end-directed
Pathways
HDACs deacetylate histones
SUMOylation of transcription factors
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Potential therapeutics for SARS
Activation of BIM and translocation to mitochondria
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Macroautophagy
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
Intraflagellar transport
RHO GTPases Activate Formins
Neutrophil degranulation
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
AURKA Activation by TPX2
HCMV Early Events
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Heel bone mineral density (
30598549
)
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Immature fraction of reticulocytes (
32888494
27863252
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Reading disability or specific language impairment (pleiotropy) (
25065397
)
Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) (
25065397
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Interacting Genes
45 interacting genes:
BCL11A
BLOC1S1
CCNH
CSNK1G2
CYSRT1
DDX18
DYNLL1
E2F1
ERCC6
ESR1
FHL3
GPR183
GRB2
H3-4
HDAC1
HDAC2
HIF1A
ITGB3BP
JUN
KHDRBS2
KPNA4
KRT31
KRT40
KRTAP10-8
LMO4
LRRK2
LZTS2
MAGEA11
MBD3L2
MNAT1
NACC2
NBPF19
NELFCD
NOTCH2NLA
PICK1
PLEKHG4
RBBP4
SAT1
SH3GL1
SH3GLB1
SUMO2
TEX11
TP53
TRIM25
UBE2I
107 interacting genes:
ACTB
ACTC1
ACTG1
ALDOA
AMOTL2
B3GALT4
BCAS1
BCL2L11
BMF
C12orf40
C14orf119
C19orf44
CA2
CACNB1
CCDC28A
CLIP2
CS
DAZ1
DCTN5
DLG4
DLGAP1
DNAJB9
DNAL4
DNM2
DNM3
DNMT1
DPPA3
DYNC1H1
DYNC1I1
EEF1A1
ERG28
FAM117B
FAM153A
FAM53B
GABARAPL1
GABARAPL2
GAPDH
GLUD1
GLUL
GNL3L
GPHN
GPRIN2
GRIN3A
HIP1R
HMBOX1
HOMER3
HSPA8
IHO1
INPP1
IQUB
KANK2
LDHA
MAP1B
MARK3
MAST2
ME2
MORN3
MRE11
MTA1
MTR
MYO10
MYO5A
NDEL1
NDUFA4L2
NFKBIA
NOS1
NRF1
NTRK1
NTRK2
NTRK3
ODF3
OR7C2
OTUD6A
PAK1
PAN2
PARD3
PAX6
PCM1
PFKM
PFKP
PKIA
PKIB
PKIG
POLH
PPP3R2
RAB4A
RACK1
RASGRP4
RGS2
SHROOM3
SLC13A1
SMCP
TERT
THAP10
THAP8
TNFRSF14
TP53BP1
TRIM54
TSNARE1
TUBA3C
TUBB
TXNDC17
VIM
ZHX1
ZMYND11
ZNF354A
ZNF710
Entrez ID
9112
8655
HPRD ID
04633
03334
Ensembl ID
ENSG00000182979
ENSG00000088986
Uniprot IDs
Q13330
Q9BRL8
P63167
Q6FGH9
PDB IDs
4BKX
4PBY
4PBZ
4PC0
5FXY
5ICN
6G16
1CMI
3ZKE
3ZKF
6GZJ
6GZL
6RLB
6SC2
Enriched GO Terms of Interacting Partners
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