TOPBP1 and CDC45

Data Source:
BioGRID (pull down)

		TOPBP1	CDC45
Description		DNA topoisomerase II binding protein 1	cell division cycle 45
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center Plasma Membrane Actin Cytoskeleton Nuclear Body PML Body Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Identical Protein Binding	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding
	Biological Process	DNA Metabolic Process DNA Replication DNA Replication Initiation DNA Repair Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Response To Ionizing Radiation Mitotic DNA Replication Checkpoint Regulation Of Signal Transduction By P53 Class Mediator	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of Chromatin Silencing At Telomere Mitotic DNA Replication Preinitiation Complex Assembly
Pathways		HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases
GWAS		Iron status biomarkers ( 19084217)	Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		32 interacting genes: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CDC45 CHEK1 CLSTN1 E2F1 ESR1 FHL3 GINS1 HUS1 PML POLE PPHLN1 PPP1CC RAD1 RAD9A RAI1 RBBP8 RHNO1 SF3B2 SMARCAD1 TBC1D4 TCFL5 TEX11 TICRR TOP2B UBR5 ZBTB17	25 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1
Entrez ID		11073	8318
HPRD ID		09678	09145
Ensembl ID		ENSG00000163781	ENSG00000093009
Uniprot IDs		A0AV47 A7E2X7 Q05BV8 Q92547	O75419
PDB IDs		1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO 6RML 6RMM	5DGO 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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