ALDH3B1 and HSD17B10

Data Source:
BioGRID (two hybrid)

		ALDH3B1	HSD17B10
Description		aldehyde dehydrogenase 3 family member B1	hydroxysteroid 17-beta dehydrogenase 10
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Secretory Granule Membrane Vesicle Specific Granule Membrane Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex Mitochondrial Nucleoid
	Molecular Function	3-chloroallyl Aldehyde Dehydrogenase Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Protein Binding Benzaldehyde Dehydrogenase (NADP+) Activity Benzaldehyde Dehydrogenase (NAD+) Activity	TRNA Binding RNA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Protein Binding Cholate 7-alpha-dehydrogenase Activity Testosterone Dehydrogenase [NAD(P)] Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
	Biological Process	Alcohol Metabolic Process Ethanol Catabolic Process Lipid Metabolic Process Sphingolipid Biosynthetic Process Cellular Response To Oxidative Stress Neutrophil Degranulation Aldehyde Catabolic Process	Isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Mitochondrion Organization C21-steroid Hormone Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Branched-chain Amino Acid Catabolic Process Protein Homotetramerization Brexanolone Metabolic Process Mitochondrial TRNA Methylation Mitochondrial TRNA Processing Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation	tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion
Drugs		NADH	NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct Omega-3-carboxylic acids
Diseases			2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Serum uric acid levels ( 32514006)	Bipolar disorder ( 31043756) Body mass index ( 28892062)
Interacting Genes		18 interacting genes: CYSRT1 HSD17B10 KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP3-3 KRTAP4-2 KRTAP5-9 MID2 NOTCH2NLA	32 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CDC42 CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 MDH1 OGDH PDHA1 PDHB PDHX PRKN PTEN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1
Entrez ID		221	3028
HPRD ID		02716	02223
Ensembl ID		ENSG00000006534	ENSG00000072506
Uniprot IDs		A0A024R5D8 A0A024R5K0 A0A087X2D4 P43353	A0A0S2Z410 Q99714
PDB IDs			1F67 1SO8 1U7T 2O23
Enriched GO Terms of Interacting Partners?
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