FBP1 and ASCC2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FBP1	ASCC2
Description		fructose-bisphosphatase 1	activating signal cointegrator 1 complex subunit 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Nuclear Speck Activating Signal Cointegrator 1 Complex
	Molecular Function	RNA Polymerase II Transcription Factor Binding Protein Binding AMP Binding Fructose 1,6-bisphosphate 1-phosphatase Activity Identical Protein Binding Metal Ion Binding Monosaccharide Binding	Protein Binding Ubiquitin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Sucrose Biosynthetic Process Fructose Metabolic Process Fructose 6-phosphate Metabolic Process Gluconeogenesis Regulation Of Gluconeogenesis Dephosphorylation Negative Regulation Of Cell Growth Fructose 1,6-bisphosphate Metabolic Process Cellular Response To Drug Negative Regulation Of Glycolytic Process Negative Regulation Of Ras Protein Signal Transduction Cellular Response To Magnesium Ion	DNA Dealkylation Involved In DNA Repair Regulation Of Transcription, DNA-templated
Pathways		Gluconeogenesis	ALKBH3 mediated reversal of alkylation damage
Drugs		Adenosine phosphate 2,5-Anhydroglucitol-1,6-Biphosphate {4-[3-(6,7-Diethoxy-Quinazolin-4-Ylamino)-Phenyl]-Thiazol-2-Yl}-Methanol Mdl-29951 Fructose-6-phosphate MB-07803 Managlinat dialanetil N-[7-(3-AMINOPHENYL)-5-METHOXY-1,3-BENZOXAZOL-2-YL]-2,5-DICHLOROBENZENESULFONAMIDE 2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE 2,5-DICHLORO-N-[5-METHOXY-7-(6-METHOXYPYRIDIN-3-YL)-1,3-BENZOXAZOL-2-YL]BENZENESULFONAMIDE 4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDE
Diseases		Fructose-1,6-bisphosphatase deficiency
GWAS		Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Colorectal or endometrial cancer ( 26621817) Obesity-related traits ( 23251661)	Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Crohn's disease ( 28067908) Hemoglobin levels ( 32327693) IgA levels ( 28628107) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin concentration ( 32888494) Refractive error ( 32231278) Telomere length ( 24478790) Tonsillectomy ( 27941131) Type 2 diabetes ( 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		38 interacting genes: ACTN1 APC ASCC2 ASL ATP5MF AXIN2 BCL10 BCL2L1 BIN1 BMPR1A BRAF BUB1 CSNK1E CTNNA1 DCC DYNC1I1 ERBB2 FBP2 FBXW7 FLCN FXR2 HDAC6 HSPA8 KLRC2 LNX1 MLH3 MSH2 PCNX4 POT1 PRKN PTK2 PTPRJ RB1 RNF183 STK11 TERF1 TLR2 TRIM28	41 interacting genes: ASS1 CKAP4 CUTC DEAF1 EEF1D ELAC2 FAF1 FBP1 FUNDC2 GADD45A GFER GNL3 GTF3C1 IGSF9 IMMT KATNAL1 KDM1A LPL MAP3K1 MED31 MYH9 OLA1 PCBD2 PIK3CD PIN4 PJA1 POLA2 POLDIP2 PRPF18 RADIL RNF11 RPA1 RPLP1 SASH1 SMURF1 SNRPB SNW1 TBC1D17 TRIP4 UBC URM1
Entrez ID		2203	84164
HPRD ID		01973	16515
Ensembl ID		ENSG00000165140	ENSG00000100325
Uniprot IDs		P09467 Q2TU34	A0A024R1E1 A0A024R1F9 Q9H1I8
PDB IDs		1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ 5PZQ 5PZR 5PZS 5PZT 5PZU 5PZV 5PZW 5PZX 5PZY 5PZZ 5Q00 5Q01 5Q02 5Q03 5Q04 5Q05 5Q06 5Q07 5Q08 5Q09 5Q0A 5Q0B 5ZWK 6LS5 6LW2 7CVN	2DI0 6YXQ
Enriched GO Terms of Interacting Partners?
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