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FBP1 and FLCN
Data Source:
BioGRID
(two hybrid)
FBP1
FLCN
Description
fructose-bisphosphatase 1
folliculin
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Extracellular Exosome
Nucleus
Cytoplasm
Lysosome
Lysosomal Membrane
Centrosome
Cytosol
Plasma Membrane
Cilium
Midbody
Cell-cell Contact Zone
Mitotic Spindle
Molecular Function
RNA Polymerase II Transcription Factor Binding
Protein Binding
AMP Binding
Fructose 1,6-bisphosphate 1-phosphatase Activity
Identical Protein Binding
Metal Ion Binding
Monosaccharide Binding
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Protein Binding
Protein-containing Complex Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Sucrose Biosynthetic Process
Fructose Metabolic Process
Fructose 6-phosphate Metabolic Process
Gluconeogenesis
Regulation Of Gluconeogenesis
Dephosphorylation
Negative Regulation Of Cell Growth
Fructose 1,6-bisphosphate Metabolic Process
Cellular Response To Drug
Negative Regulation Of Glycolytic Process
Negative Regulation Of Ras Protein Signal Transduction
Cellular Response To Magnesium Ion
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Cell-cell Junction Assembly
Cellular Response To Starvation
Positive Regulation Of Autophagy
Negative Regulation Of Gene Expression
Negative Regulation Of Mitochondrion Organization
Hemopoiesis
Negative Regulation Of Cell Growth
Negative Regulation Of Cell Migration
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
TOR Signaling
Regulation Of TOR Signaling
Negative Regulation Of TOR Signaling
Positive Regulation Of TOR Signaling
Lysosome Localization
Regulation Of Cytokinesis
Cellular Response To Amino Acid Starvation
Negative Regulation Of Rho Protein Signal Transduction
Regulation Of Histone Acetylation
Positive Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of ERK1 And ERK2 Cascade
Energy Homeostasis
Negative Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of Cell Proliferation Involved In Kidney Development
Negative Regulation Of Brown Fat Cell Differentiation
Positive Regulation Of TORC1 Signaling
Regulation Of Pro-B Cell Differentiation
Negative Regulation Of ATP Biosynthetic Process
Pathways
Gluconeogenesis
Amino acids regulate mTORC1
Drugs
Adenosine phosphate
2,5-Anhydroglucitol-1,6-Biphosphate
{4-[3-(6,7-Diethoxy-Quinazolin-4-Ylamino)-Phenyl]-Thiazol-2-Yl}-Methanol
Mdl-29951
Fructose-6-phosphate
MB-07803
Managlinat dialanetil
N-[7-(3-AMINOPHENYL)-5-METHOXY-1,3-BENZOXAZOL-2-YL]-2,5-DICHLOROBENZENESULFONAMIDE
2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE
2,5-DICHLORO-N-[5-METHOXY-7-(6-METHOXYPYRIDIN-3-YL)-1,3-BENZOXAZOL-2-YL]BENZENESULFONAMIDE
4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDE
Diseases
Fructose-1,6-bisphosphatase deficiency
Renal cell carcinoma
Birt-Hogg-Dube syndrome
GWAS
Cerebrospinal fluid t-tau:AB1-42 ratio (
28641921
)
Colorectal or endometrial cancer (
26621817
)
Obesity-related traits (
23251661
)
Heel bone mineral density (
30598549
)
Mean reticulocyte volume (
32888494
)
Interacting Genes
38 interacting genes:
ACTN1
APC
ASCC2
ASL
ATP5MF
AXIN2
BCL10
BCL2L1
BIN1
BMPR1A
BRAF
BUB1
CSNK1E
CTNNA1
DCC
DYNC1I1
ERBB2
FBP2
FBXW7
FLCN
FXR2
HDAC6
HSPA8
KLRC2
LNX1
MLH3
MSH2
PCNX4
POT1
PRKN
PTK2
PTPRJ
RB1
RNF183
STK11
TERF1
TLR2
TRIM28
11 interacting genes:
ALDOB
APP
CCDC180
FBP1
GABARAP
HEMGN
HSP90AA1
MAP1LC3B
NANS
TMEFF1
TSTD2
Entrez ID
2203
201163
HPRD ID
01973
06278
Ensembl ID
ENSG00000165140
ENSG00000154803
Uniprot IDs
P09467
Q2TU34
A0A0S2Z5Y7
Q8NFG4
PDB IDs
1FTA
2FHY
2FIE
2FIX
2JJK
2VT5
2WBB
2WBD
2Y5K
2Y5L
3A29
3KBZ
3KC0
3KC1
4MJO
5LDZ
5PZQ
5PZR
5PZS
5PZT
5PZU
5PZV
5PZW
5PZX
5PZY
5PZZ
5Q00
5Q01
5Q02
5Q03
5Q04
5Q05
5Q06
5Q07
5Q08
5Q09
5Q0A
5Q0B
5ZWK
6LS5
6LW2
7CVN
3V42
6NZD
6ULG
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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