Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
FBP1 and MSH2
Data Source:
BioGRID
(two hybrid)
FBP1
MSH2
Description
fructose-bisphosphatase 1
mutS homolog 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Extracellular Exosome
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Membrane
Mismatch Repair Complex
MutSalpha Complex
MutSbeta Complex
Molecular Function
RNA Polymerase II Transcription Factor Binding
Protein Binding
AMP Binding
Fructose 1,6-bisphosphate 1-phosphatase Activity
Identical Protein Binding
Metal Ion Binding
Monosaccharide Binding
Magnesium Ion Binding
Four-way Junction DNA Binding
Double-strand/single-strand DNA Junction Binding
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
ATPase Activity
Centromeric DNA Binding
Enzyme Binding
Protein Kinase Binding
Mismatched DNA Binding
Guanine/thymine Mispair Binding
Dinucleotide Insertion Or Deletion Binding
Single Guanine Insertion Binding
Single Thymine Insertion Binding
Dinucleotide Repeat Insertion Binding
Oxidized Purine DNA Binding
MutLalpha Complex Binding
Protein Homodimerization Activity
ADP Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Sucrose Biosynthetic Process
Fructose Metabolic Process
Fructose 6-phosphate Metabolic Process
Gluconeogenesis
Regulation Of Gluconeogenesis
Dephosphorylation
Negative Regulation Of Cell Growth
Fructose 1,6-bisphosphate Metabolic Process
Cellular Response To Drug
Negative Regulation Of Glycolytic Process
Negative Regulation Of Ras Protein Signal Transduction
Cellular Response To Magnesium Ion
In Utero Embryonic Development
Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response
Oxidative Phosphorylation
DNA Repair
Mismatch Repair
Postreplication Repair
Double-strand Break Repair
DNA Recombination
Cell Cycle Arrest
Germ Cell Development
Determination Of Adult Lifespan
Male Gonad Development
Response To X-ray
Response To UV-B
Somatic Hypermutation Of Immunoglobulin Genes
Somatic Recombination Of Immunoglobulin Gene Segments
B Cell Mediated Immunity
B Cell Differentiation
Intra-S DNA Damage Checkpoint
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Neuron Apoptotic Process
Maintenance Of DNA Repeat Elements
Isotype Switching
Negative Regulation Of DNA Recombination
Positive Regulation Of Isotype Switching To IgA Isotypes
Positive Regulation Of Isotype Switching To IgG Isotypes
Positive Regulation Of Helicase Activity
Protein Localization To Chromatin
Pathways
Gluconeogenesis
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Defective Mismatch Repair Associated With MSH3
Defective Mismatch Repair Associated With MSH2
Defective Mismatch Repair Associated With MSH6
TP53 Regulates Transcription of DNA Repair Genes
Drugs
Adenosine phosphate
2,5-Anhydroglucitol-1,6-Biphosphate
{4-[3-(6,7-Diethoxy-Quinazolin-4-Ylamino)-Phenyl]-Thiazol-2-Yl}-Methanol
Mdl-29951
Fructose-6-phosphate
MB-07803
Managlinat dialanetil
N-[7-(3-AMINOPHENYL)-5-METHOXY-1,3-BENZOXAZOL-2-YL]-2,5-DICHLOROBENZENESULFONAMIDE
2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE
2,5-DICHLORO-N-[5-METHOXY-7-(6-METHOXYPYRIDIN-3-YL)-1,3-BENZOXAZOL-2-YL]BENZENESULFONAMIDE
4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDE
Diseases
Fructose-1,6-bisphosphatase deficiency
Colorectal cancer
Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
Ovarian cancer
GWAS
Cerebrospinal fluid t-tau:AB1-42 ratio (
28641921
)
Colorectal or endometrial cancer (
26621817
)
Obesity-related traits (
23251661
)
Electroencephalogram traits (
25387704
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Interacting Genes
38 interacting genes:
ACTN1
APC
ASCC2
ASL
ATP5MF
AXIN2
BCL10
BCL2L1
BIN1
BMPR1A
BRAF
BUB1
CSNK1E
CTNNA1
DCC
DYNC1I1
ERBB2
FBP2
FBXW7
FLCN
FXR2
HDAC6
HSPA8
KLRC2
LNX1
MLH3
MSH2
PCNX4
POT1
PRKN
PTK2
PTPRJ
RB1
RNF183
STK11
TERF1
TLR2
TRIM28
48 interacting genes:
AKT1
ANXA7
APPBP2
ATR
BARD1
BRCA1
CCDC180
CDC14B
CDC42
CDKN1A
CHEK2
CREBBP
DVL1
EPHA2
ESR1
ESR2
EXO1
FBP1
FBP2
FGFR4
GALNT12
GRB7
HDAC6
HRAS
HUS1
LEF1
MAX
MSH3
MSH6
MYC
PCNA
PPP3R2
RAD1
RAD9A
RPA4
RPP14
SMAD1
SMC1A
SMN1
STX17
SUMO2
TDRD7
TK1
TREX1
TRIM29
USP10
XPA
ZNF510
Entrez ID
2203
4436
HPRD ID
01973
00389
Ensembl ID
ENSG00000165140
ENSG00000095002
Uniprot IDs
P09467
Q2TU34
A0A2R8Y6P0
P43246
PDB IDs
1FTA
2FHY
2FIE
2FIX
2JJK
2VT5
2WBB
2WBD
2Y5K
2Y5L
3A29
3KBZ
3KC0
3KC1
4MJO
5LDZ
5PZQ
5PZR
5PZS
5PZT
5PZU
5PZV
5PZW
5PZX
5PZY
5PZZ
5Q00
5Q01
5Q02
5Q03
5Q04
5Q05
5Q06
5Q07
5Q08
5Q09
5Q0A
5Q0B
5ZWK
6LS5
6LW2
7CVN
2O8B
2O8C
2O8D
2O8E
2O8F
3THW
3THX
3THY
3THZ
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?