PPP1R32 and PLA2G10

Data Source:
BioGRID (two hybrid)

		PPP1R32	PLA2G10
Description		protein phosphatase 1 regulatory subunit 32	phospholipase A2 group X
Image		No pdb structure
GO Annotations	Cellular Component	Ciliary Basal Body	Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome
	Molecular Function	Protein Binding Phosphatase Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
	Biological Process		Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidylserine Metabolic Process Axon Guidance Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Arachidonic Acid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Cholesterol Homeostasis Regulation Of Macrophage Activation Negative Regulation Of DNA-binding Transcription Factor Activity Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Arachidonic Acid Secretion Defense Response To Virus Lysophospholipid Transport Platelet Activating Factor Catabolic Process Positive Regulation Of Arachidonic Acid Secretion Negative Regulation Of Cholesterol Efflux Positive Regulation Of Acrosome Reaction
Pathways			Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs			Varespladib methyl Crotalus adamanteus antivenin Agkistrodon piscivorus antivenin
Diseases
GWAS		Spatial memory ( 31596458)	Cholesteryl ester levels ( 31551469) Glycerophospholipid levels ( 26068415)
Interacting Genes		72 interacting genes: AKAP8L ALS2CL APP ATN1 ATPAF2 B9D2 BAG4 BCAS2 C10orf55 CATSPER1 CCDC57 COG6 COX5B CSTF2 CTDSP1 CYSRT1 DTX2 FAM168B FHL2 FHL3 FHL5 FKBP6 FRS3 GOLGA2 HGS HNRNPH1 HOMER3 HOXA1 HSF2BP INCA1 KCTD9 KPRP KRT31 KRTAP13-2 KRTAP19-5 KRTAP19-6 KRTAP3-1 KRTAP3-2 KRTAP6-2 KRTAP6-3 KRTAP8-1 LASP1 LMO2 LMO4 METTL27 MYO15B OIP5 OTUD7B PFDN5 PLA2G10 PLEKHG4 PLEKHN1 PPP1CA PPP1CC PRDM14 PRKAA2 QARS1 RBM11 RFX6 RIMBP3C SLAIN1 TEKT4 TFG TGM7 TRAF1 TRAF2 TRIB3 TSC1 UNKL VMAC WWOX ZMYND12	49 interacting genes: AGXT AQP1 ARID5A ATXN1 BAG3 BEX2 C1orf94 CATSPER1 CCDC120 CREB5 CYSRT1 FAM222B FOXH1 GATA5 GNE HGS HOXC8 HR HSF4 INCA1 KPRP KRTAP11-1 KRTAP26-1 LCE1A LCE1C LCE2A LCE2B LCE2D MAL MAPKBP1 MGAT5B MYO10 NOXA1 NTAQ1 OTX1 PITX1 PLA2R1 POU4F3 PPP1R32 ROR2 SNRPC SPAG8 STK16 TBX6 TFG TLX3 VGLL3 VPS37C ZC3H10
Entrez ID		220004	8399
HPRD ID		16933	04674
Ensembl ID		ENSG00000162148	ENSG00000069764
Uniprot IDs		G3F4G3 Q7Z5V6	O15496
PDB IDs			1LE6 1LE7 4UY1 5G3M 5OW8 5OWC 6G5J
Enriched GO Terms of Interacting Partners?
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