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EWSR1 and IRF3
Data Source:
BioGRID
(two hybrid)
EWSR1
IRF3
Description
EWS RNA binding protein 1
interferon regulatory factor 3
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Plasma Membrane
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Molecular Function
Transcription Coregulator Activity
RNA Binding
Protein Binding
Calmodulin Binding
Identical Protein Binding
Metal Ion Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Protein Domain Specific Binding
Identical Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Regulation Of Transcription, DNA-templated
Negative Regulation Of Transcription By RNA Polymerase II
Immune System Process
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Cellular Response To DNA Damage Stimulus
Viral Process
Lipopolysaccharide-mediated Signaling Pathway
Regulation Of Type I Interferon Production
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
TRIF-dependent Toll-like Receptor Signaling Pathway
MDA-5 Signaling Pathway
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Inflammatory Response
Defense Response To Virus
Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Cellular Response To Exogenous DsRNA
Macrophage Apoptotic Process
Programmed Necrotic Cell Death
Cellular Response To Virus
Pathways
ISG15 antiviral mechanism
IRF3 mediated activation of type 1 IFN
IRF3 mediated activation of type 1 IFN
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Regulation of innate immune responses to cytosolic DNA
IRF3-mediated induction of type I IFN
Interferon gamma signaling
TICAM1-dependent activation of IRF3/IRF7
Interferon alpha/beta signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
Ewing's sarcoma
Myxoid liposarcoma
Clear cell sarcoma of soft tissue
Extraskeletal myxoid chondrosarcoma
GWAS
Breast cancer (
23535729
)
Pancreatic cancer (
25086665
)
Platelet count (
27863252
)
Platelet distribution width (
32888494
)
Autoimmune thyroid disease (
32581359
)
Schizophrenia (
29483656
)
Vitiligo (
27723757
)
Interacting Genes
162 interacting genes:
ACTL6A
AGT
ANXA11
ARID1A
ATN1
ATPAF2
ATXN3
BAD
BARD1
BLZF1
BNIP3L
BRME1
BTK
C11orf16
CALM1
CCDC7
CCDC91
CD177
CDK12
CEACAM5
CETP
CFDP1
CHERP
CNST
CPSF6
CPSF7
CREBBP
CUEDC2
CXADR
DFFA
DMRTB1
DNAJB3
DYNLL2
E2F8
ECD
ELAVL3
ELAVL4
ELK1
EPAS1
ERCC5
FAM131C
FASN
FLI1
FUS
FXR2
GNPDA1
GPBP1L1
H2BC15
HBP1
HDAC3
HERPUD1
HLTF
HMGA1
HMGN4
HNRNPUL1
HSPA2
IRF3
ITCH
ITGB5
JUN
KCNMB1
KEL
KHDRBS2
KRR1
KXD1
LILRA3
MAGEA11
MAPK1IP1L
MATK
MDFI
MNS1
MRPS18B
MSC
MTCP1
MTMR9
MVK
MYL6
MYO1F
MYOZ2
NBPF3
NDRG1
NDUFB1
NDUFV1
NINL
NLE1
NONO
NPPB
NSUN4
NTNG2
PCBP1
PDHX
PEF1
PGLS
PLSCR1
POLR2G
POLR3A
POU4F1
POU5F1
PRKCA
PRMT1
PRMT8
PRR13
PRRC2A
PRTFDC1
PRUNE2
PTK2B
RAB37
RAD23A
RALYL
RASL11B
RBPMS
RFX3
RHOXF2
RMND5B
RNF183
RPL31
RPS15A
SALL2
SCMH1
SEC24A
SEC24D
SELENOI
SERP2
SF1
SF3B4
SLC1A1
SLC22A24
SMAD1
SMAD4
SMARCC1
SMARCC2
SNRPC
SSBP2
SSBP3
SUPT4H1
SUV39H2
TAF1
TFG
TMSB4Y
TONSL
TPGS2
TRAF1
TRAF2
TRAF3
TRIM37
TRIM5
TRPV5
TSPAN3
TULP2
USP7
VPS72
WBP4
WDR37
WWP1
WWP2
YWHAG
YY1AP1
ZBTB1
ZDHHC3
ZNF165
ZNF184
ZNF383
30 interacting genes:
CREBBP
EP300
EWSR1
FBXO7
GRIP1
HERC5
HSP90AA1
IKBKE
IRF5
IRF7
MAPK8
MAVS
PEX19
PIAS4
PPIB
PRDX1
RB1
RBL1
RELA
SERPINB2
SGTA
SMURF2
SYT1
TBK1
TICAM1
TICAM2
TOMM70
TRIM26
TRIM55
TRIM63
Entrez ID
2130
3661
HPRD ID
00592
04769
Ensembl ID
ENSG00000182944
ENSG00000126456
Uniprot IDs
Q01844
E2GIM5
E2GIM6
E2GIM7
E2GIM8
E2GIM9
M0QYT9
Q14653
PDB IDs
2CPE
1J2F
1QWT
1T2K
1ZOQ
2O61
2O6G
2PI0
3A77
3QU6
5JEJ
5JEK
5JEL
5JEM
5JEO
5JER
6SIV
6SJA
7JFL
Enriched GO Terms of Interacting Partners
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