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IRF3 and SGTA
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
IRF3
SGTA
Description
interferon regulatory factor 3
small glutamine rich tetratricopeptide repeat co-chaperone alpha
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Nucleus
Cytoplasm
Cytosol
Membrane
TRC Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Protein Domain Specific Binding
Identical Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Protein Binding
Identical Protein Binding
Protein Self-association
Molecular Adaptor Activity
BAT3 Complex Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Immune System Process
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Cellular Response To DNA Damage Stimulus
Viral Process
Lipopolysaccharide-mediated Signaling Pathway
Regulation Of Type I Interferon Production
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
TRIF-dependent Toll-like Receptor Signaling Pathway
MDA-5 Signaling Pathway
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Inflammatory Response
Defense Response To Virus
Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Cellular Response To Exogenous DsRNA
Macrophage Apoptotic Process
Programmed Necrotic Cell Death
Cellular Response To Virus
Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane
Viral Process
Ubiquitin-dependent ERAD Pathway
Tail-anchored Membrane Protein Insertion Into ER Membrane
Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Chaperone-mediated Protein Folding
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
ISG15 antiviral mechanism
IRF3 mediated activation of type 1 IFN
IRF3 mediated activation of type 1 IFN
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Regulation of innate immune responses to cytosolic DNA
IRF3-mediated induction of type I IFN
Interferon gamma signaling
TICAM1-dependent activation of IRF3/IRF7
Interferon alpha/beta signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS
Autoimmune thyroid disease (
32581359
)
Schizophrenia (
29483656
)
Vitiligo (
27723757
)
Interacting Genes
30 interacting genes:
CREBBP
EP300
EWSR1
FBXO7
GRIP1
HERC5
HSP90AA1
IKBKE
IRF5
IRF7
MAPK8
MAVS
PEX19
PIAS4
PPIB
PRDX1
RB1
RBL1
RELA
SERPINB2
SGTA
SMURF2
SYT1
TBK1
TICAM1
TICAM2
TOMM70
TRIM26
TRIM55
TRIM63
176 interacting genes:
ADAM21
ADIPOQ
ADRM1
AGR2
AGR3
AOC3
BAG6
BCL2L12
BTC
C1QA
C1QL4
C1QTNF1
C1QTNF5
C1QTNF6
C3orf52
C5orf46
CD79B
CD99
CD99L2
CDH15
CDSN
CHRNG
COL1A2
COL8A2
CREB3L3
CSF1
CST1
CTAG1A
CTAG1B
CTSL
CXCL8
CYB5R1
DEFB131A
DKK3
DMKN
EDA2R
EDAR
EFEMP1
EFEMP2
ERP27
ERP29
ETNK1
EVA1B
F11R
FERD3L
FGF21
FIP1L1
FKBP7
FSTL1
FXYD2
FXYD7
FZD7
GABARAPL2
GAL
GALP
GHR
GIP
GPX7
GRN
GUCA2A
GYPA
HSP90AA1
HSP90AB1
HSPA13
HSPA4
HSPA8
IER3
IGFBP6
IGL
IGLC1
IL6ST
IRF3
IRF5
ITPRIPL1
KASH5
KCNA1
KCNA10
KCNE5
KRT6A
KTN1
LAIR2
LAT
LCN2
LDLRAD4
LSMEM2
MRAP2
MS4A3
MSMB
MSTN
MYDGF
MYOC
NAXD
NME3
NPVF
NR3C1
NRSN2
NXF1
PAGE3
PBXIP1
PCDHA4
PCDHGA4
PFN2
PGLYRP2
PGR
PIAS1
PLAAT4
PMEPA1
PPIB
PPIC
PPP1R3C
PRAP1
PRB4
PRRG2
PSORS1C2
PTN
PYY
RCN1
RNASE10
RNF144A
RNF144B
RNF170
RPN1
SDC4
SDF2L1
SERPINE1
SERPINI2
SGCA
SGTB
SHISA4
SHISA5
SLPI
SMAGP
SMIM14
SMIM5
SOD3
SPINK9
SPN
SPP1
SPPL2A
SRGN
SRL
STMP1
SUOX
SYT11
SYT4
TFF3
TFRC
TGFA
TMEM154
TMEM174
TMEM230
TMEM31
TMEM98
TMPO
TMPRSS11D
TMUB2
TNFRSF10C
TNFRSF13B
TNFRSF19
TNFRSF1A
TNFRSF21
TNFSF12
TRIM5
TWSG1
TXNDC12
UBL4A
UBQLN2
UPK3A
VIP
WBP1L
WFDC12
WFDC13
WFDC5
ZBTB8B
ZG16
ZG16B
Entrez ID
3661
6449
HPRD ID
04769
04568
Ensembl ID
ENSG00000126456
ENSG00000104969
Uniprot IDs
E2GIM5
E2GIM6
E2GIM7
E2GIM8
E2GIM9
M0QYT9
Q14653
O43765
PDB IDs
1J2F
1QWT
1T2K
1ZOQ
2O61
2O6G
2PI0
3A77
3QU6
5JEJ
5JEK
5JEL
5JEM
5JEO
5JER
6SIV
6SJA
7JFL
2VYI
4CPG
4GOD
4GOE
4GOF
Enriched GO Terms of Interacting Partners
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