IRF3 and TOMM70

Data Source:
BioGRID (pull down)

		IRF3	TOMM70
Description		interferon regulatory factor 3	translocase of outer mitochondrial membrane 70
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Protein Transmembrane Transporter Activity Mitochondrion Targeting Sequence Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Transcription By RNA Polymerase II Apoptotic Process Cellular Response To DNA Damage Stimulus Viral Process Lipopolysaccharide-mediated Signaling Pathway Regulation Of Type I Interferon Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Macrophage Apoptotic Process Programmed Necrotic Cell Death Cellular Response To Virus	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Protein Targeting To Mitochondrion Macroautophagy Protein Import Into Mitochondrial Matrix Positive Regulation Of Interferon-beta Production Regulation Of Apoptotic Process Protein Insertion Into Mitochondrial Inner Membrane Cellular Response To Virus
Pathways		ISG15 antiviral mechanism IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Schizophrenia ( 29483656) Vitiligo ( 27723757)
Interacting Genes		30 interacting genes: CREBBP EP300 EWSR1 FBXO7 GRIP1 HERC5 HSP90AA1 IKBKE IRF5 IRF7 MAPK8 MAVS PEX19 PIAS4 PPIB PRDX1 RB1 RBL1 RELA SERPINB2 SGTA SMURF2 SYT1 TBK1 TICAM1 TICAM2 TOMM70 TRIM26 TRIM55 TRIM63	7 interacting genes: HSP90AA1 HSPA1A HSPA1B HSPB1 IRF3 PRKN SNAPIN
Entrez ID		3661	9868
HPRD ID		04769	16194
Ensembl ID		ENSG00000126456	ENSG00000154174
Uniprot IDs		E2GIM5 E2GIM6 E2GIM7 E2GIM8 E2GIM9 M0QYT9 Q14653	O94826
PDB IDs		1J2F 1QWT 1T2K 1ZOQ 2O61 2O6G 2PI0 3A77 3QU6 5JEJ 5JEK 5JEL 5JEM 5JEO 5JER 6SIV 6SJA 7JFL	7KDT
Enriched GO Terms of Interacting Partners?
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