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EWSR1 and AGT
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
EWSR1
AGT
Description
EWS RNA binding protein 1
angiotensinogen
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Plasma Membrane
Extracellular Region
Extracellular Space
Cytosol
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Molecular Function
Transcription Coregulator Activity
RNA Binding
Protein Binding
Calmodulin Binding
Identical Protein Binding
Metal Ion Binding
Serine-type Endopeptidase Inhibitor Activity
Hormone Activity
Protein Binding
Growth Factor Activity
Type 1 Angiotensin Receptor Binding
Type 2 Angiotensin Receptor Binding
Biological Process
Regulation Of Transcription, DNA-templated
Activation Of MAPK Activity
Regulation Of Cell Growth
Positive Regulation Of Cytokine Production
Kidney Development
Blood Vessel Remodeling
Regulation Of Blood Volume By Renin-angiotensin
Renin-angiotensin Regulation Of Aldosterone Production
Regulation Of Renal Output By Angiotensin
Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin
Renal System Process
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Nitric Oxide Mediated Signal Transduction
Cell-cell Signaling
Regulation Of Blood Pressure
Positive Regulation Of Activation Of Janus Kinase Activity
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Esterification
Negative Regulation Of Endopeptidase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Response To Muscle Activity Involved In Regulation Of Muscle Adaptation
Regulation Of Lipid Metabolic Process
Regulation Of Vasoconstriction
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of NAD(P)H Oxidase Activity
Low-density Lipoprotein Particle Remodeling
Regulation Of Renal Sodium Excretion
Regulation Of Cell Population Proliferation
Vasoconstriction
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Inflammatory Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Protein Tyrosine Kinase Activity
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Regulation Of Extracellular Matrix Assembly
Positive Regulation Of Gap Junction Assembly
Regulation Of Cardiac Conduction
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
PPARA activates gene expression
Metabolism of Angiotensinogen to Angiotensins
Metabolism of Angiotensinogen to Angiotensins
Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
Drugs
Zinc
Copper
Sparsentan
Zinc acetate
Diseases
Ewing's sarcoma
Myxoid liposarcoma
Clear cell sarcoma of soft tissue
Extraskeletal myxoid chondrosarcoma
Renal tubular dysgenesis
GWAS
Breast cancer (
23535729
)
Pancreatic cancer (
25086665
)
Platelet count (
27863252
)
Platelet distribution width (
32888494
)
Blood protein levels (
30072576
)
Coronary artery disease (
29212778
33020668
)
Diastolic blood pressure (
27841878
28739976
27618452
)
Diastolic blood pressure (cigarette smoking interaction) (
29455858
)
Diastolic blood pressure x alcohol consumption interaction (2df test) (
29912962
)
Mean arterial pressure (
27618448
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Pancreatic ductal adenocarcinoma (
30541042
)
Response to cognitive-behavioural therapy in anxiety disorder (
31123309
)
Systolic blood pressure (
27841878
27618452
30578418
)
Systolic blood pressure (cigarette smoking interaction) (
29455858
)
Systolic blood pressure x alcohol consumption interaction (2df test) (
29912962
)
Interacting Genes
162 interacting genes:
ACTL6A
AGT
ANXA11
ARID1A
ATN1
ATPAF2
ATXN3
BAD
BARD1
BLZF1
BNIP3L
BRME1
BTK
C11orf16
CALM1
CCDC7
CCDC91
CD177
CDK12
CEACAM5
CETP
CFDP1
CHERP
CNST
CPSF6
CPSF7
CREBBP
CUEDC2
CXADR
DFFA
DMRTB1
DNAJB3
DYNLL2
E2F8
ECD
ELAVL3
ELAVL4
ELK1
EPAS1
ERCC5
FAM131C
FASN
FLI1
FUS
FXR2
GNPDA1
GPBP1L1
H2BC15
HBP1
HDAC3
HERPUD1
HLTF
HMGA1
HMGN4
HNRNPUL1
HSPA2
IRF3
ITCH
ITGB5
JUN
KCNMB1
KEL
KHDRBS2
KRR1
KXD1
LILRA3
MAGEA11
MAPK1IP1L
MATK
MDFI
MNS1
MRPS18B
MSC
MTCP1
MTMR9
MVK
MYL6
MYO1F
MYOZ2
NBPF3
NDRG1
NDUFB1
NDUFV1
NINL
NLE1
NONO
NPPB
NSUN4
NTNG2
PCBP1
PDHX
PEF1
PGLS
PLSCR1
POLR2G
POLR3A
POU4F1
POU5F1
PRKCA
PRMT1
PRMT8
PRR13
PRRC2A
PRTFDC1
PRUNE2
PTK2B
RAB37
RAD23A
RALYL
RASL11B
RBPMS
RFX3
RHOXF2
RMND5B
RNF183
RPL31
RPS15A
SALL2
SCMH1
SEC24A
SEC24D
SELENOI
SERP2
SF1
SF3B4
SLC1A1
SLC22A24
SMAD1
SMAD4
SMARCC1
SMARCC2
SNRPC
SSBP2
SSBP3
SUPT4H1
SUV39H2
TAF1
TFG
TMSB4Y
TONSL
TPGS2
TRAF1
TRAF2
TRAF3
TRIM37
TRIM5
TRPV5
TSPAN3
TULP2
USP7
VPS72
WBP4
WDR37
WWP1
WWP2
YWHAG
YY1AP1
ZBTB1
ZDHHC3
ZNF165
ZNF184
ZNF383
23 interacting genes:
ACE2
AGTR1
AGTR2
ATP6AP2
CMA1
CTSG
DNPEP
ECE1
ENPEP
EWSR1
GRB2
GSDMB
ITSN2
KNG1
LNPEP
MAS1
MEP1A
MME
PRCP
PREP
PRG2
REN
TP53
Entrez ID
2130
183
HPRD ID
00592
00106
Ensembl ID
ENSG00000182944
ENSG00000135744
Uniprot IDs
Q01844
B0ZBE2
B2R5S1
P01019
PDB IDs
2CPE
1N9U
1N9V
2JP8
2WXW
2X0B
3CK0
3WOO
3WOR
4AA1
4APH
4FYS
5E2Q
5M3X
5M3Y
5XJM
6I3F
6I3I
6JOD
6OS0
7C6A
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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