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HSPA9 and TP53
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro, in vivo)
HSPA9
TP53
Description
heat shock protein family A (Hsp70) member 9
tumor protein p53
Image
GO Annotations
Cellular Component
SAM Complex
Nucleolus
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Focal Adhesion
Mitochondrial Nucleoid
Extracellular Exosome
MIB Complex
Chromatin
Nucleus
Nucleoplasm
Replication Fork
Transcription Regulator Complex
Transcription Factor TFIID Complex
Nucleolus
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Endoplasmic Reticulum
Centrosome
Cytosol
Nuclear Matrix
Nuclear Body
PML Body
Protein-containing Complex
Site Of Double-strand Break
Molecular Function
RNA Binding
Protein Binding
ATP Binding
ATPase Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Protein Folding Chaperone
Unfolded Protein Binding
Misfolded Protein Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding
TFIID-class Transcription Factor Complex Binding
DNA-binding Transcription Activator Activity
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protease Binding
P53 Binding
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
MRNA 3'-UTR Binding
Copper Ion Binding
Protein Binding
ATP Binding
Transcription Factor Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Protein Phosphatase Binding
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Histone Deacetylase Regulator Activity
Histone Acetyltransferase Binding
Identical Protein Binding
Histone Deacetylase Binding
Protein Self-association
Protein Heterodimerization Activity
Protein N-terminus Binding
Chaperone Binding
Protein Phosphatase 2A Binding
MDM2/MDM4 Family Protein Binding
Disordered Domain Specific Binding
Promoter-specific Chromatin Binding
Biological Process
Protein Export From Nucleus
Inner Mitochondrial Membrane Organization
Iron-sulfur Cluster Assembly
Erythrocyte Differentiation
Cellular Response To Unfolded Protein
Interleukin-12-mediated Signaling Pathway
Protein Refolding
Negative Regulation Of Apoptotic Process
Regulation Of Erythrocyte Differentiation
Negative Regulation Of Erythrocyte Differentiation
Chaperone Cofactor-dependent Protein Refolding
Negative Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Hemopoiesis
Negative Regulation Of Transcription By RNA Polymerase II
DNA Strand Renaturation
In Utero Embryonic Development
Somitogenesis
Release Of Cytochrome C From Mitochondria
Hematopoietic Progenitor Cell Differentiation
T Cell Proliferation Involved In Immune Response
B Cell Lineage Commitment
T Cell Lineage Commitment
Response To Ischemia
Nucleotide-excision Repair
Double-strand Break Repair
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Protein Import Into Nucleus
Autophagy
Cellular Response To DNA Damage Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
ER Overload Response
Cell Cycle Arrest
Transforming Growth Factor Beta Receptor Signaling Pathway
Ras Protein Signal Transduction
Gastrulation
Negative Regulation Of Neuroblast Proliferation
Cell Aging
Protein Localization
Negative Regulation Of DNA Replication
Negative Regulation Of Cell Population Proliferation
Determination Of Adult Lifespan
MRNA Transcription
RRNA Transcription
Response To Salt Stress
Response To X-ray
Response To Gamma Radiation
Positive Regulation Of Gene Expression
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Viral Process
Protein Deubiquitination
Cytokine-mediated Signaling Pathway
Cerebellum Development
Negative Regulation Of Cell Growth
DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Histone Deacetylation
Chromatin Assembly
Mitotic G1 DNA Damage Checkpoint
T Cell Differentiation In Thymus
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Tissue Remodeling
Cellular Response To UV
Multicellular Organism Growth
Cellular Response To Drug
Positive Regulation Of Mitochondrial Membrane Permeability
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Cellular Response To Glucose Starvation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Entrainment Of Circadian Clock By Photoperiod
Mitochondrial DNA Repair
Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of Proteolysis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Positive Regulation Of Transcription By RNA Polymerase II
Response To Antibiotic
Positive Regulation Of Protein Export From Nucleus
Negative Regulation Of Fibroblast Proliferation
Circadian Behavior
Bone Marrow Development
Embryonic Organ Development
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Protein Stabilization
Negative Regulation Of Helicase Activity
Protein Tetramerization
Neuron Apoptotic Process
Negative Regulation Of Telomerase Activity
Hematopoietic Stem Cell Differentiation
Interferon-gamma-mediated Signaling Pathway
Cardiac Septum Morphogenesis
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Positive Regulation Of Programmed Necrotic Cell Death
Protein-containing Complex Assembly
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Positive Regulation Of Thymocyte Apoptotic Process
Necroptotic Process
Positive Regulation Of Cell Cycle Arrest
Cellular Response To Hypoxia
Cellular Response To Ionizing Radiation
Cellular Response To Gamma Radiation
Cellular Response To UV-C
Mitotic Cell Cycle Arrest
Signal Transduction By P53 Class Mediator
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Cellular Response To Actinomycin D
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Positive Regulation Of Cell Aging
Replicative Senescence
Oxidative Stress-induced Premature Senescence
Intrinsic Apoptotic Signaling Pathway
Oligodendrocyte Apoptotic Process
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Negative Regulation Of Mitophagy
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Regulation Of Cell Cycle G2/M Phase Transition
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate
Negative Regulation Of Pentose-phosphate Shunt
Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia
Regulation Of Transcription From RNA Polymerase II Promoter In Response To DNA Damage
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Regulation Of Fibroblast Apoptotic Process
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Regulation Of Cellular Senescence
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Mitochondrial protein import
Regulation of HSF1-mediated heat shock response
Cristae formation
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Activation of NOXA and translocation to mitochondria
Activation of PUMA and translocation to mitochondria
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Oncogene Induced Senescence
DNA Damage/Telomere Stress Induced Senescence
SUMOylation of transcription factors
Autodegradation of the E3 ubiquitin ligase COP1
Association of TriC/CCT with target proteins during biosynthesis
TP53 Regulates Metabolic Genes
Ub-specific processing proteases
Ovarian tumor domain proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Interleukin-4 and Interleukin-13 signaling
TP53 Regulates Transcription of DNA Repair Genes
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Caspase Activators and Caspases
TP53 Regulates Transcription of Death Receptors and Ligands
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Expression
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
Regulation of TP53 Activity through Methylation
PI5P Regulates TP53 Acetylation
G2/M DNA damage checkpoint
G2/M Checkpoints
Stabilization of p53
Transcriptional activation of cell cycle inhibitor p21
The role of GTSE1 in G2/M progression after G2 checkpoint
Transcriptional Regulation by VENTX
RUNX3 regulates CDKN1A transcription
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Factors involved in megakaryocyte development and platelet production
Drugs
Acetylsalicylic acid
Zinc
Triethyl phosphate
AZD 3355
1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Osteosarcoma
Adrenal carcinoma
Thyroid cancer
Breast cancer
Basal cell carcinoma
Malignant melanoma
Pancreatic cancer
Gastric cancer
Malignant pleural mesothelioma
Non-small cell lung cancer
Esophageal cancer
Oral cancer
Multiple myeloma
Small cell lung cancer
Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL)
Glioma
Squamous cell carcinoma
Kaposi's sarcoma
Cholangiocarcinoma
Gallbladder cancer
Cancer of the anal canal
Hepatocellular carcinoma
Choriocarcinoma
Vulvar cancer
Choroid plexus papilloma
Burkitt lymphoma
Adult T-cell leukemia
Hairy-cell leukemia
Bladder cancer
Chronic lymphocytic leukemia (CLL)
Penile cancer
Endometrial Cancer
Ovarian cancer
Colorectal cancer
Laryngeal cancer
Chronic myeloid leukemia (CML)
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Cerebrospinal AB1-42 levels in Alzheimer's disease dementia (
29274321
)
Schizophrenia (
25056061
29483656
)
Basal cell carcinoma (
31174203
24403052
25855136
27539887
21946351
)
Birth weight (
31043758
)
Brain morphology (MOSTest) (
32665545
)
Cancer (
28346444
)
Cutaneous malignant melanoma (
32341527
)
Diastolic blood pressure (
28135244
27841878
30578418
)
Esophageal squamous cell carcinoma (
25129146
)
Glioblastoma (
28346443
29743610
)
Glioblastoma (age-stratified) (
30152087
)
Glioma (
28346443
29743610
)
Keratinocyte cancer (MTAG) (
31174203
)
LDL cholesterol levels (
32203549
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
28346444
31624269
)
Nevus count or cutaneous melanoma (
32341527
)
Non-glioblastoma glioma (
28346443
29743610
)
Pulse pressure (
28135244
27841878
30578418
)
Red blood cell count (
32888494
)
Sex hormone levels (
26014426
)
Sporadic neuroblastoma (
28545128
)
Uterine fibroids (
31249589
30194396
31649266
)
Interacting Genes
26 interacting genes:
APP
DNAJC19
DNLZ
ERBB2
ERCC6
FGF1
HSP90B1
HSPBP1
LAMTOR5
LINC01554
LSM8
MATK
MVD
NELFB
PTPN11
PTPRF
SIRPA
STUB1
SUMO2
SUMO4
SUPT6H
TIMM44
TP53
XPO1
YKT6
YWHAG
489 interacting genes:
ABL1
ACKR3
ACTA1
AGT
AKAP5
AKT1
ANK2
ANKRD2
ANTKMT
ANXA2
ANXA3
APBB2
APEX1
APOH
APPL1
APTX
ARAF
ARID1A
ARID3A
ARIH2
ARL3
ARNT
ASH2L
ATF3
ATM
ATR
ATRX
ATXN3
AURKA
AXIN1
BAG5
BAG6
BAIAP2L1
BAK1
BANP
BARD1
BAX
BCCIP
BCL2
BCL2L1
BCL2L12
BCL2L2
BCL6
BCR
BLM
BMP1
BRCA1
BRCA2
BRF1
BTBD2
BTK
C10orf90
CABLES1
CABLES2
CAPG
CAPN1
CARM1
CBLC
CCDC106
CCL18
CCNA2
CCNG1
CCNH
CCT5
CD40LG
CDC14A
CDC14B
CDC25C
CDC34
CDC42
CDK1
CDK2
CDK4
CDK5
CDK6
CDK7
CDK8
CDK9
CDKN1A
CDKN2A
CDKN2B
CDKN2C
CEBPZ
CENPX
CETP
CHD3
CHEK1
CHEK2
CHUK
COP1
COPS2
COPS3
COPS4
COPS5
COPS6
COPS7A
COPS8
COX17
CR2
CRBN
CREBBP
CREBZF
CRK
CSNK1A1
CSNK1D
CSNK2A1
CSNK2A2
CSNK2B
CUL9
CXXC1
CYLD
DAPK3
DAXX
DCAF1
DDX20
DDX5
DGKZ
DHCR24
DHFR
DLEU1
DMTF1
DNAJB1
DNAJC7
DNMT3L
DTL
DVL2
E2F1
E4F1
EAF2
EEF2
EFEMP2
EGLN3
EGR1
EHMT1
EHMT2
EIF2AK2
EIF2S2
ELL
ELL3
EP300
EPHA2
EPHA3
ERBB2
ERCC2
ERCC3
ERCC6
ERH
ESR1
FBXO11
FBXO42
FBXW7
FCAMR
FGFR4
FOS
FOXO3
FXYD6
FZR1
GADD45A
GNL3
GPS1
GPS2
GPX2
GRWD1
GSK3B
GSTM4
GTF2H1
GTF2H4
GYS2
HABP4
HDAC1
HDAC2
HDAC3
HECTD3
HECW1
HEY1
HIF1A
HINFP
HIPK1
HIPK2
HMGA2
HMGB1
HMGB2
HNF4A
HNRNPUL1
HSP90AA1
HSP90AB1
HSP90B1
HSPA1A
HSPA9
HSPB1
HTT
HUWE1
IFI16
IKBKB
ING1
ING4
ING5
IRF7
ITPK1
JDP2
JUN
KAT2A
KAT2B
KAT5
KAT6A
KAT7
KAT8
KDM1A
KDM4D
KIAA0087
KLF4
KLF6
KMT5A
KPNA2
KPNA4
KPNB1
LACTB
LAMA4
LAMTOR5
LATS2
LDB3
MAD2L1BP
MAGEA2
MAGEB18
MAML1
MAP2K3
MAP2K5
MAP3K1
MAPK1
MAPK10
MAPK14
MAPK3
MAPK8
MAPK9
MAPKAPK5
MDC1
MDH1
MDM2
MDM4
MED1
MED17
MED21
MEN1
MET
MIF
MKRN2
MNAT1
MNDA
MPHOSPH6
MSL2
MSX1
MTA1
MTA2
MUC1
MUL1
MVP
MYBBP1A
MYC
NABP1
NABP2
NAP1L1
NAT10
NCL
NCOA1
NCOA2
NCOA3
NDN
NEDD8
NEIL3
NF2
NFKBIA
NFYA
NFYB
NGFR
NMT1
NMT2
NOP53
NPM1
NQO1
NR0B2
NR3C1
NR4A1
NTHL1
OTUB1
OTUD5
PADI1
PAFAH1B3
PARP1
PBK
PCDHA4
PDGFRA
PDLIM7
PELI1
PELI2
PELP1
PER2
PHB
PIAS1
PIAS2
PIAS4
PIN1
PLAGL1
PLCG2
PLK1
PLK3
PML
PNP
POLA1
PPA1
PPARGC1A
PPIB
PPM1D
PPP1CA
PPP1CC
PPP1R13L
PPP2CA
PPP2R2B
PPP4C
PRIM1
PRKAB2
PRKCA
PRKD1
PRKDC
PRKN
PRKRA
PRMT1
PRPF8
PSMB3
PSMC5
PSMD11
PSMD4
PSME3
PTEN
PTGS2
PTK2
PTTG1
RAB4A
RAB7A
RAD51
RANBP9
RAP1B
RB1
RBBP6
RBCK1
RBPJ
RCHY1
RELA
RING1
RNF125
RNF128
RNF38
RPA1
RPS6KA1
RPS6KA2
RPS6KA3
RRM2
RRM2B
RUNX3
S100A2
S100A4
S100A6
S100A8
S100B
SAT1
SCAMP1
SERPINB9
SETD7
SFN
SHISA5
SIN3A
SIN3B
SIRT1
SLC9A9
SMAD2
SMAD3
SMARCA4
SMARCB1
SMARCD1
SMN1
SMYD2
SNRPN
SP1
SP3
SRC
SRSF1
SSTR3
STAMBP
STARD10
STAT6
STK11
STK4
STX5
SUB1
SULT1E1
SUMO1
SYVN1
TADA3
TAF1
TAF1A
TAF1B
TAF1C
TAF9
TAF9B
TBP
TCF4
TEAD2
TEC
TEP1
TFAP2A
TFAP2C
TFDP1
TFIP11
THAP12
THAP8
THRB
TIAF1
TK1
TOP1
TOP1MT
TOP2A
TOP2B
TOPORS
TP53BP1
TP53BP2
TP53INP1
TP53RK
TP63
TP73
TRIAP1
TRIM27
TRIM39
TRIM67
TSC22D1
TSG101
TTK
TWIST1
TXN
UBB
UBE2A
UBE2D1
UBE2D3
UBE2I
UBE2K
UBE2L3
UBE2M
UBE2N
UBE2Q1
UBE2V2
UBE3A
UFD1
UHRF1
UHRF2
UIMC1
USP11
USP21
USP24
USP28
USP3
USP42
USP49
USP7
UTP14A
VRK1
WDR33
WDR5
WDR82
WRN
WT1
WWOX
XAF1
XPO1
XRCC6
YBX1
YWHAG
YWHAZ
YY1
YY2
ZBTB2
ZBTB49
ZCCHC10
ZHX1
ZIC3
ZMIZ2
ZNF148
ZNF24
ZNF302
ZNF679
ZNF839
ZNHIT1
Entrez ID
3313
7157
HPRD ID
02770
01859
Ensembl ID
ENSG00000113013
ENSG00000141510
Uniprot IDs
A0A384P5G6
P38646
A0A087WT22
A0A087WXZ1
A0A087X1Q1
H2EHT1
K7PPA8
P04637
Q53GA5
PDB IDs
3N8E
4KBO
6NHK
6P2U
6PMT
1A1U
1AIE
1C26
1DT7
1GZH
1H26
1HS5
1JSP
1KZY
1MA3
1OLG
1OLH
1PES
1PET
1SAE
1SAF
1SAK
1SAL
1TSR
1TUP
1UOL
1XQH
1YC5
1YCQ
1YCR
1YCS
2AC0
2ADY
2AHI
2ATA
2B3G
2BIM
2BIN
2BIO
2BIP
2BIQ
2F1X
2FEJ
2FOJ
2FOO
2GS0
2H1L
2H2D
2H2F
2H4F
2H4H
2H4J
2H59
2J0Z
2J10
2J11
2J1W
2J1X
2J1Y
2J1Z
2J20
2J21
2K8F
2L14
2LY4
2MEJ
2MWO
2MWP
2MWY
2MZD
2OCJ
2PCX
2RUK
2VUK
2WGX
2X0U
2X0V
2X0W
2XWR
2YBG
2YDR
2Z5S
2Z5T
3D05
3D06
3D07
3D08
3D09
3D0A
3DAB
3DAC
3IGK
3IGL
3KMD
3KZ8
3LW1
3OQ5
3PDH
3Q01
3Q05
3Q06
3SAK
3TG5
3TS8
3ZME
4AGL
4AGM
4AGN
4AGO
4AGP
4AGQ
4BUZ
4BV2
4HFZ
4HJE
4IBQ
4IBS
4IBT
4IBU
4IBV
4IBW
4IBY
4IBZ
4IJT
4KVP
4LO9
4LOE
4LOF
4MZI
4MZR
4QO1
4RP6
4RP7
4X34
4XR8
4ZZJ
5A7B
5AB9
5ABA
5AOI
5AOJ
5AOK
5AOL
5AOM
5BUA
5ECG
5G4M
5G4N
5G4O
5HOU
5HP0
5HPD
5LAP
5LGY
5MCT
5MCU
5MCV
5MCW
5MF7
5MG7
5MHC
5MOC
5O1A
5O1B
5O1C
5O1D
5O1E
5O1F
5O1G
5O1H
5O1I
5OL0
5UN8
5XZC
6FF9
6FJ5
6GGA
6GGB
6GGC
6GGD
6GGE
6GGF
6R5L
6RJZ
6RK8
6RKI
6RKK
6RKM
6RL3
6RL4
6RL6
6RM5
6RM7
6RWH
6RWI
6RWS
6RWU
6RX2
6RZ3
6S39
6S3C
6S40
6S9Q
6SHZ
6SI0
6SI1
6SI2
6SI3
6SI4
6SIN
6SIO
6SIP
6SIQ
6SL6
6SLV
6T58
6V4F
6V4H
6VQO
6VR1
6VR5
6VRM
6VRN
7BWN
Enriched GO Terms of Interacting Partners
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