ERCC8 and UQCRQ

Data Source:
HPRD (two hybrid)

		ERCC8	UQCRQ
Description		ERCC excision repair 8, CSA ubiquitin ligase complex subunit	ubiquinol-cytochrome c reductase complex III subunit VII
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Cul4A-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Perikaryon Cul4-RING E3 Ubiquitin Ligase Complex	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex III Integral Component Of Membrane
	Molecular Function	DNA Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding DNA-dependent ATPase Activity Protein-containing Complex Binding	Ubiquinol-cytochrome-c Reductase Activity
	Biological Process	Single Strand Break Repair Protein Polyubiquitination Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Response To UV Response To X-ray Response To Auditory Stimulus Response To Organic Cyclic Compound DNA Duplex Unwinding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of DNA Repair Protein Autoubiquitination Double-strand Break Repair Via Classical Nonhomologous End Joining	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Subthalamus Development Pons Development Cerebellar Purkinje Cell Layer Development Hippocampus Development Thalamus Development Hypothalamus Development Pyramidal Neuron Development Midbrain Development
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	Respiratory electron transport
Drugs			2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome Cockayne syndrome	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Asthma ( 31619474)
Interacting Genes		11 interacting genes: CAMK2D CBR1 CSNK2B CUL4A DDB1 ERCC6 GTF2H2 RBX1 TOP1 UQCRQ XAB2	4 interacting genes: ERCC6 ERCC8 OPTN POLR2M
Entrez ID		1161	27089
HPRD ID		07523	17941
Ensembl ID		ENSG00000049167	ENSG00000164405
Uniprot IDs		A0A0S2Z3L1 B3KPW7 B4DGZ9 Q13216	O14949
PDB IDs		4A11 6FCV	5XTE 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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