ERCC1 and MKRN3

Data Source:
BioGRID (two hybrid)

		ERCC1	MKRN3
Description		ERCC excision repair 1, endonuclease non-catalytic subunit	makorin ring finger protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nucleoplasm Cytoplasm ERCC4-ERCC1 Complex	Ribonucleoprotein Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding	Protein Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Meiotic Mismatch Repair Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Mitotic Recombination Syncytium Formation Response To Oxidative Stress Spermatogenesis Response To Nutrient Cell Population Proliferation Male Gonad Development UV Protection Response To Sucrose Response To X-ray Multicellular Organism Aging Negative Regulation Of Telomere Maintenance Nucleotide-excision Repair, DNA Incision Post-embryonic Hemopoiesis Multicellular Organism Growth Response To Immobilization Stress Interstrand Cross-link Repair Isotype Switching Response To Cadmium Ion Oogenesis Embryonic Organ Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Telomeric DNA-containing Double Minutes Formation Global Genome Nucleotide-excision Repair UV-damage Excision Repair Replicative Senescence T-circle Formation Positive Regulation Of T-circle Formation Negative Regulation Of Protection From Non-homologous End Joining At Telomere	Protein Polyubiquitination Protein Ubiquitination
Pathways		HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Simvastatin-induced myopathy ( 31220337)	Height ( 31562340) Menarche (age at onset) ( 25231870) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		18 interacting genes: APP CHRM5 ERCC4 GAS8 KIF11 MKRN3 RAD52 RPA1 RPA2 RPA3 SLX1A TRMT2B UBL7 UHRF1 USHBP1 USP45 VPS37B XPA	178 interacting genes: ACOT11 ADAMTSL4 ADRA2C ANKRD11 ANTKMT APEX2 AQP1 ARID5A ARMC5 AVPI1 BATF2 BCL2L11 BEX2 BLZF1 BPIFA1 C10orf82 C21orf58 CCDC120 CCDC185 CCDC187 CCDC33 CDCA4 CEP70 CERCAM CRACR2A CYSRT1 DDIT4L ECM1 ECSIT EFEMP1 ENKD1 ERCC1 FAM110A FAM124B FAM214B FARS2 GADD45GIP1 GATA1 GEM GOLGA6A GRAP2 HCK HGS HOXA1 HOXD12 HSF2BP HSF4 IGF1 IKZF3 INO80B KANK2 KIF1A KIFC3 KLF1 KLHL38 KRT34 KRT75 KRT86 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP6-2 KRTAP7-1 KRTAP8-1 LAGE3 LASP1 LRSAM1 MAGED1 MBD3 MCCD1 MDM2 MDM4 MEOX1 MEOX2 MGAT5B MIF4GD MNAT1 MORN3 MRPL38 MRPS6 MYOZ2 NABP1 NDE1 NDUFB7 NKAPD1 NME4 ODAD4 ODF3B PEX10 PEX5 PKN1 POLR1C POMC PRKAA2 PRPF31 PRR22 PRR35 PSMA1 PSMB1 PTH1R PTK6 RASD1 RBM41 RBPMS RBPMS2 RIBC1 RNF166 RNF32 RNF7 RSPO4 RTP5 SCNM1 SF1 SFN SLPI SMARCD1 SMYD3 SNRPC SORBS3 SPATA8 STH STMN3 STN1 SYNGAP1 TADA2A TASOR2 TCEA2 TCHP TCL1B TENT5B TFAP2A TFIP11 TLE5 TPRX1 TRAF2 TRIM23 TRIM31 TRIM34 TRIM5 TRIM65 TRIM8 TSG101 TSGA10IP TSPAN4 TTC23 TXNDC11 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L3 UBE2N UBE2U UBE2V1 UBE2V2 UBE2W UQCC2 USHBP1 VPS9D1 WDR25 WWOX YPEL3 ZBTB42 ZFC3H1 ZFP57 ZIM2 ZNF34 ZNF414 ZNF587 ZNF688 ZNF835
Entrez ID		2067	7681
HPRD ID		00533	04836
Ensembl ID		ENSG00000012061	ENSG00000179455
Uniprot IDs		A0A024R0Q6 P07992	Q13064
PDB IDs		1Z00 2A1I 2A1J 2JNW 2JPD 2MUT 6SXA 6SXB
Enriched GO Terms of Interacting Partners?
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