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ERBB3 and LYN
Data Source:
BioGRID
(pull down)
ERBB3
LYN
Description
erb-b2 receptor tyrosine kinase 3
LYN proto-oncogene, Src family tyrosine kinase
Image
GO Annotations
Cellular Component
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Basal Plasma Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
ERBB3:ERBB2 Complex
Receptor Complex
Nucleus
Cytoplasm
Mitochondrial Intermembrane Space
Golgi Apparatus
Cytosol
Plasma Membrane
Adherens Junction
Postsynaptic Density
Mitochondrial Crista
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Integrin Alpha2-beta1 Complex
Intracellular Membrane-bounded Organelle
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Postsynaptic Specialization, Intracellular Component
Molecular Function
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane Signaling Receptor Activity
Protein Binding
ATP Binding
Growth Factor Binding
Protein Tyrosine Kinase Activator Activity
Ubiquitin Protein Ligase Binding
Neuregulin Receptor Activity
Neuregulin Binding
Identical Protein Binding
ErbB-3 Class Receptor Binding
Protein Heterodimerization Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Kinase Activity
SH3 Domain Binding
Ubiquitin Protein Ligase Binding
Gamma-tubulin Binding
Glycosphingolipid Binding
Ion Channel Binding
Ephrin Receptor Binding
Phosphoprotein Binding
Phosphorylation-dependent Protein Binding
Biological Process
MAPK Cascade
Endocardial Cushion Development
Negative Regulation Of Cell Adhesion
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Nervous System Development
Peripheral Nervous System Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Signal Transduction
Positive Regulation Of Gene Expression
Schwann Cell Differentiation
Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cranial Nerve Development
Positive Regulation Of Kinase Activity
ERBB2 Signaling Pathway
Wound Healing
Regulation Of Cell Population Proliferation
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Secretion
Neuron Apoptotic Process
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Cardiac Muscle Tissue Development
Positive Regulation Of Protein Tyrosine Kinase Activity
Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Cell Motility
B Cell Homeostasis
Regulation Of Cytokine Production
Regulation Of Protein Phosphorylation
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Fc Receptor Mediated Stimulatory Signaling Pathway
Tolerance Induction To Self Antigen
Histamine Secretion By Mast Cell
Platelet Degranulation
Negative Regulation Of Myeloid Leukocyte Differentiation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Fc Receptor Mediated Inhibitory Signaling Pathway
Regulation Of B Cell Apoptotic Process
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
Response To Sterol Depletion
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Blood Coagulation
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Toxic Substance
Response To Hormone
Response To Carbohydrate
Positive Regulation Of Neuron Projection Development
Oligodendrocyte Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Response To Organic Cyclic Compound
Viral Process
Peptidyl-tyrosine Phosphorylation
Cell Differentiation
Platelet Activation
Erythrocyte Differentiation
Positive Regulation Of Cell Migration
Negative Regulation Of B Cell Proliferation
Neuron Projection Development
T Cell Costimulation
Lipopolysaccharide-mediated Signaling Pathway
Cellular Response To Extracellular Stimulus
Response To Insulin
Regulation Of Mast Cell Activation
Regulation Of Cell Adhesion Mediated By Integrin
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Cellular Response To Heat
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Response To Drug
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Response To Amino Acid
Regulation Of Mast Cell Degranulation
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Regulation Of Erythrocyte Differentiation
Positive Regulation Of Ras Protein Signal Transduction
Protein Autophosphorylation
Ephrin Receptor Signaling Pathway
Response To Axon Injury
Regulation Of Inflammatory Response
Negative Regulation Of Immune Response
B Cell Receptor Signaling Pathway
Regulation Of B Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Cellular Component Movement
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Glial Cell Proliferation
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Oligodendrocyte Progenitor Proliferation
Negative Regulation Of Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Cellular Response To Retinoic Acid
Regulation Of Monocyte Chemotaxis
Regulation Of Platelet Aggregation
Dendritic Cell Differentiation
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Dendritic Cell Apoptotic Process
Pathways
GPVI-mediated activation cascade
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
Dectin-2 family
CD209 (DC-SIGN) signaling
CD22 mediated BCR regulation
Cyclin D associated events in G1
Platelet Adhesion to exposed collagen
Signaling by Erythropoietin
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Growth hormone receptor signaling
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Tucatinib
Dasatinib
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Bosutinib
Ponatinib
Nintedanib
Fostamatinib
Diseases
Lethal congenital contractural syndrome (LCCS)
Type I diabetes mellitus
GWAS
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Alopecia areata (
25608926
)
Anorexia nervosa (
28494655
)
Asthma (
31959851
30929738
31619474
)
Asthma (adult onset) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Autoimmune thyroid disease (
32581359
)
Brain morphology (MOSTest) (
32665545
)
Cognitive function (
25644384
)
Household income (MTAG) (
31844048
)
Hypothyroidism (
27182965
)
Obesity-related traits (
23251661
)
Polycystic ovary syndrome (
26416764
)
Refractive error (
32231278
)
Smoking initiation (
30617275
)
Type 1 diabetes (
21829393
19430480
18198356
17554260
17554300
30572963
18978792
)
Vitiligo (
22951725
)
Granulocyte count (
27863252
)
Height (
18391951
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
27863252
)
Platelet count (
32888494
)
Refractive error (
32231278
)
Serum thyroid-stimulating hormone levels (
24852370
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systemic lupus erythematosus (
28714469
)
White blood cell count (
29403010
32888494
27863252
)
Interacting Genes
193 interacting genes:
ABL1
ABL2
ACYP1
AGTR2
ALDOA
ATP5ME
BCAR3
BEND5
BLK
BLNK
BTK
CALM1
CD82
CDC25C
CDK5
CFL1
CHN2
CRK
CRKL
CSPG5
DAB1
DAPP1
DUSP14
DUSP18
DUSP19
DUSP21
DUSP29
EGF
EGFR
EGR1
ENOPH1
ERBB2
ERBB4
ERG28
EYA4
EZR
FAM241B
FER
FES
FGFR1
FGR
FHL3
FKBP1A
FLNA
FLYWCH1
GABARAPL1
GABARAPL2
GRAP2
GRB2
GRB7
HCK
HDAC6
HINT1
HSH2D
HSPA1A
HSPA8
IL6ST
ILKAP
INPPL1
IRF2BP2
ITK
JAK2
JAK3
JUP
LAMTOR2
LBHD1
LCK
LCP2
LRRC7
LYN
MAP1B
MATK
MTMR1
MTMR10
MTMR2
MTMR6
MTMR8
MTMR9
MUC1
MUC4
MYCBP
MYCBP2
NCK1
NCK2
NDUFAB1
NEDD4
NRG1
NRG2
NSMCE1
ODF2L
PA2G4
PDGFRA
PFDN2
PFDN4
PHPT1
PIK3R1
PIK3R2
PIK3R3
PIN4
PLCG1
PLCG2
PPM1A
PPM1B
PPM1F
PPM1K
PPM1M
PRDX5
PRKACA
PRRG4
PSMA5
PTEN
PTGES3
PTK2
PTK2B
PTK6
PTPDC1
PTPN11
PTPN12
PTPN20
PTPN6
PTPN7
PTPRH
PTPRR
RALGAPA1
RASA1
RASA4
RGS4
RIN1
RNF41
RPN1
RTN4
RWDD2A
S100A10
SAP18
SELENOK
SF3B6
SH2B1
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3A
SH2D3C
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SHD
SLA
SLA2
SMIM20
SNAP91
SNRPB2
SOCS2
SOCS3
SOCS5
SOCS6
SOS1
SRC
SRPK2
STAP1
STYX
SYK
SYNM
TBCA
TCEA2
TEC
TMA7
TMEM134
TMEM14A
TMEM230
TNS1
TNS2
TNS3
TNS4
TPTE
TRIR
TVP23B
TXK
TXN
TXNL4A
VAV1
VAV2
VAV3
VTA1
WRNIP1
YES1
YWHAZ
ZAP70
ZNF207
ZNF532
125 interacting genes:
ACTB
ADAM15
AR
BANK1
BCAR1
BTK
CASP3
CASP7
CASP9
CBL
CBLC
CD19
CD22
CD36
CD72
CD79A
CD79B
CDK1
CDK2
CDKN1B
CHST15
COASY
CREBBP
CRKL
CSF1R
CSF2RA
CSF2RB
CSF3R
CSK
CSNK2B
CTLA4
DAPP1
DLG4
DOK1
DOK2
DOK3
EGFR
EPOR
ERBB2
ERBB3
ERBB4
EVL
FASLG
FCAR
FCER1G
FCGR2A
FCGR2B
FOLR1
GAB1
GAB2
GAB3
GP6
GRIA3
HCLS1
HNRNPK
IGHA1
IL1B
IL2RB
IL7R
INPP5D
ITPR1
JAK2
KHDRBS1
KIT
LCP2
LIME1
MAP4K1
MAPK3
MATK
MET
MME
MS4A1
MS4A2
MUC1
NDFIP2
NEDD9
NMT1
NPHS1
PAG1
PAK2
PDE4A
PDE4D
PECAM1
PIK3CG
PILRB
PLCG1
PLCG2
PPP1R15A
PPP1R8
PRAM1
PRKCD
PRKCQ
PRKDC
PTK2
PTK2B
PTPN6
PTPRC
RASA1
RGS16
RPL10
RPS6KB1
RPS6KB2
SH2B2
SHC1
SKAP1
SKAP2
SLC4A1
SNCA
SPHK1
SPHK2
SRC
STAT3
SYK
TEC
TNF
TRAT1
TRIM28
TRIM55
TRIM63
TRIP10
TRPV4
TYK2
UBB
UHRF2
UNC119
Entrez ID
2065
4067
HPRD ID
01820
01301
Ensembl ID
ENSG00000065361
ENSG00000254087
Uniprot IDs
P21860
A8K379
P07948
Q6NUK7
PDB IDs
1M6B
2L9U
3KEX
3LMG
3P11
4LEO
4P59
4RIW
4RIX
4RIY
5CUS
5O4O
5O7P
6KBI
6OP9
1W1F
1WA7
3A4O
5XY1
6NMW
Enriched GO Terms of Interacting Partners
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