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ERBB3 and DUSP18
Data Source:
BioGRID
(two hybrid)
ERBB3
DUSP18
Description
erb-b2 receptor tyrosine kinase 3
dual specificity phosphatase 18
Image
GO Annotations
Cellular Component
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Basal Plasma Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
ERBB3:ERBB2 Complex
Receptor Complex
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Inner Membrane
Molecular Function
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane Signaling Receptor Activity
Protein Binding
ATP Binding
Growth Factor Binding
Protein Tyrosine Kinase Activator Activity
Ubiquitin Protein Ligase Binding
Neuregulin Receptor Activity
Neuregulin Binding
Identical Protein Binding
ErbB-3 Class Receptor Binding
Protein Heterodimerization Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Protein Tyrosine/serine/threonine Phosphatase Activity
Phosphatase Activity
MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Biological Process
MAPK Cascade
Endocardial Cushion Development
Negative Regulation Of Cell Adhesion
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Nervous System Development
Peripheral Nervous System Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Signal Transduction
Positive Regulation Of Gene Expression
Schwann Cell Differentiation
Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cranial Nerve Development
Positive Regulation Of Kinase Activity
ERBB2 Signaling Pathway
Wound Healing
Regulation Of Cell Population Proliferation
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Secretion
Neuron Apoptotic Process
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Cardiac Muscle Tissue Development
Positive Regulation Of Protein Tyrosine Kinase Activity
Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Cell Motility
Inactivation Of MAPK Activity
Dephosphorylation
Peptidyl-tyrosine Dephosphorylation
Peptidyl-threonine Dephosphorylation
Pathways
Drugs
Tucatinib
Diseases
Lethal congenital contractural syndrome (LCCS)
Type I diabetes mellitus
GWAS
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Alopecia areata (
25608926
)
Anorexia nervosa (
28494655
)
Asthma (
31959851
30929738
31619474
)
Asthma (adult onset) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Autoimmune thyroid disease (
32581359
)
Brain morphology (MOSTest) (
32665545
)
Cognitive function (
25644384
)
Household income (MTAG) (
31844048
)
Hypothyroidism (
27182965
)
Obesity-related traits (
23251661
)
Polycystic ovary syndrome (
26416764
)
Refractive error (
32231278
)
Smoking initiation (
30617275
)
Type 1 diabetes (
21829393
19430480
18198356
17554260
17554300
30572963
18978792
)
Vitiligo (
22951725
)
Interacting Genes
193 interacting genes:
ABL1
ABL2
ACYP1
AGTR2
ALDOA
ATP5ME
BCAR3
BEND5
BLK
BLNK
BTK
CALM1
CD82
CDC25C
CDK5
CFL1
CHN2
CRK
CRKL
CSPG5
DAB1
DAPP1
DUSP14
DUSP18
DUSP19
DUSP21
DUSP29
EGF
EGFR
EGR1
ENOPH1
ERBB2
ERBB4
ERG28
EYA4
EZR
FAM241B
FER
FES
FGFR1
FGR
FHL3
FKBP1A
FLNA
FLYWCH1
GABARAPL1
GABARAPL2
GRAP2
GRB2
GRB7
HCK
HDAC6
HINT1
HSH2D
HSPA1A
HSPA8
IL6ST
ILKAP
INPPL1
IRF2BP2
ITK
JAK2
JAK3
JUP
LAMTOR2
LBHD1
LCK
LCP2
LRRC7
LYN
MAP1B
MATK
MTMR1
MTMR10
MTMR2
MTMR6
MTMR8
MTMR9
MUC1
MUC4
MYCBP
MYCBP2
NCK1
NCK2
NDUFAB1
NEDD4
NRG1
NRG2
NSMCE1
ODF2L
PA2G4
PDGFRA
PFDN2
PFDN4
PHPT1
PIK3R1
PIK3R2
PIK3R3
PIN4
PLCG1
PLCG2
PPM1A
PPM1B
PPM1F
PPM1K
PPM1M
PRDX5
PRKACA
PRRG4
PSMA5
PTEN
PTGES3
PTK2
PTK2B
PTK6
PTPDC1
PTPN11
PTPN12
PTPN20
PTPN6
PTPN7
PTPRH
PTPRR
RALGAPA1
RASA1
RASA4
RGS4
RIN1
RNF41
RPN1
RTN4
RWDD2A
S100A10
SAP18
SELENOK
SF3B6
SH2B1
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3A
SH2D3C
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SHD
SLA
SLA2
SMIM20
SNAP91
SNRPB2
SOCS2
SOCS3
SOCS5
SOCS6
SOS1
SRC
SRPK2
STAP1
STYX
SYK
SYNM
TBCA
TCEA2
TEC
TMA7
TMEM134
TMEM14A
TMEM230
TNS1
TNS2
TNS3
TNS4
TPTE
TRIR
TVP23B
TXK
TXN
TXNL4A
VAV1
VAV2
VAV3
VTA1
WRNIP1
YES1
YWHAZ
ZAP70
ZNF207
ZNF532
14 interacting genes:
EPHA2
EPHA3
EPHA7
EPHB6
ERBB2
ERBB3
ERBB4
IGF1R
INSR
MAPK8IP2
PTK7
ROR1
ROR2
TEK
Entrez ID
2065
150290
HPRD ID
01820
13253
Ensembl ID
ENSG00000065361
ENSG00000167065
Uniprot IDs
P21860
A0A024R1L2
F2Z2P2
Q8NEJ0
PDB IDs
1M6B
2L9U
3KEX
3LMG
3P11
4LEO
4P59
4RIW
4RIX
4RIY
5CUS
5O4O
5O7P
6KBI
6OP9
2ESB
Enriched GO Terms of Interacting Partners
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