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ERBB3 and ERBB2
Data Source:
HPRD
(in vivo, in vitro)
ERBB3
ERBB2
Description
erb-b2 receptor tyrosine kinase 3
erb-b2 receptor tyrosine kinase 2
Image
GO Annotations
Cellular Component
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Basal Plasma Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
ERBB3:ERBB2 Complex
Receptor Complex
Nucleus
Early Endosome
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Basal Plasma Membrane
Endosome Membrane
Integral Component Of Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
ERBB3:ERBB2 Complex
Myelin Sheath
Receptor Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane Signaling Receptor Activity
Protein Binding
ATP Binding
Growth Factor Binding
Protein Tyrosine Kinase Activator Activity
Ubiquitin Protein Ligase Binding
Neuregulin Receptor Activity
Neuregulin Binding
Identical Protein Binding
ErbB-3 Class Receptor Binding
Protein Heterodimerization Activity
RNA Polymerase I Core Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane Signaling Receptor Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Growth Factor Binding
Protein Phosphatase Binding
Identical Protein Binding
ErbB-3 Class Receptor Binding
Protein Heterodimerization Activity
Biological Process
MAPK Cascade
Endocardial Cushion Development
Negative Regulation Of Cell Adhesion
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Nervous System Development
Peripheral Nervous System Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Signal Transduction
Positive Regulation Of Gene Expression
Schwann Cell Differentiation
Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cranial Nerve Development
Positive Regulation Of Kinase Activity
ERBB2 Signaling Pathway
Wound Healing
Regulation Of Cell Population Proliferation
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Secretion
Neuron Apoptotic Process
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Cardiac Muscle Tissue Development
Positive Regulation Of Protein Tyrosine Kinase Activity
Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Cell Motility
MAPK Cascade
Positive Regulation Of Protein Phosphorylation
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Signal Transduction
Cell Surface Receptor Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Peripheral Nervous System Development
Heart Development
Neuromuscular Junction Development
Motor Neuron Axon Guidance
Positive Regulation Of Cell Population Proliferation
Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Neuron Differentiation
Positive Regulation Of Cell Growth
Regulation Of Microtubule-based Process
Negative Regulation Of Immature T Cell Proliferation In Thymus
Positive Regulation Of Kinase Activity
Intracellular Signal Transduction
ERBB2 Signaling Pathway
Wound Healing
Myelination
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of GTPase Activity
Positive Regulation Of Translation
Regulation Of Angiogenesis
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription By RNA Polymerase I
Protein Autophosphorylation
Oligodendrocyte Differentiation
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Kinase B Signaling
Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Protein Targeting To Membrane
Negative Regulation Of ERBB Signaling Pathway
Regulation Of Cell Motility
Pathways
Signaling by ERBB2
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
PLCG1 events in ERBB2 signaling
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Sema4D induced cell migration and growth-cone collapse
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Constitutive Signaling by Overexpressed ERBB2
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
Drugs
Tucatinib
Trastuzumab
Lapatinib
IGN311
Trastuzumab emtansine
Varlitinib
AV-412
Pertuzumab
Afatinib
Tucatinib
Tesevatinib
Fostamatinib
Brigatinib
Margetuximab
Zanubrutinib
Diseases
Lethal congenital contractural syndrome (LCCS)
Type I diabetes mellitus
Choriocarcinoma
Pancreatic cancer
Gastric cancer
Bladder cancer
Endometrial Cancer
Ovarian cancer
Cholangiocarcinoma
Breast cancer
Cervical cancer
GWAS
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Alopecia areata (
25608926
)
Anorexia nervosa (
28494655
)
Asthma (
31959851
30929738
31619474
)
Asthma (adult onset) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Autoimmune thyroid disease (
32581359
)
Brain morphology (MOSTest) (
32665545
)
Cognitive function (
25644384
)
Household income (MTAG) (
31844048
)
Hypothyroidism (
27182965
)
Obesity-related traits (
23251661
)
Polycystic ovary syndrome (
26416764
)
Refractive error (
32231278
)
Smoking initiation (
30617275
)
Type 1 diabetes (
21829393
19430480
18198356
17554260
17554300
30572963
18978792
)
Vitiligo (
22951725
)
Adult asthma (
30787307
)
Asthma (
31619474
29273806
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Bipolar disorder (
27329760
)
Estimated glomerular filtration rate (
31451708
)
Pancreatic ductal adenocarcinoma (
30541042
)
Polycystic ovary syndrome (
26416764
)
Refractive error (
32231278
)
Systemic lupus erythematosus (
26502338
28714469
)
Ulcerative colitis (
20228799
)
Interacting Genes
193 interacting genes:
ABL1
ABL2
ACYP1
AGTR2
ALDOA
ATP5ME
BCAR3
BEND5
BLK
BLNK
BTK
CALM1
CD82
CDC25C
CDK5
CFL1
CHN2
CRK
CRKL
CSPG5
DAB1
DAPP1
DUSP14
DUSP18
DUSP19
DUSP21
DUSP29
EGF
EGFR
EGR1
ENOPH1
ERBB2
ERBB4
ERG28
EYA4
EZR
FAM241B
FER
FES
FGFR1
FGR
FHL3
FKBP1A
FLNA
FLYWCH1
GABARAPL1
GABARAPL2
GRAP2
GRB2
GRB7
HCK
HDAC6
HINT1
HSH2D
HSPA1A
HSPA8
IL6ST
ILKAP
INPPL1
IRF2BP2
ITK
JAK2
JAK3
JUP
LAMTOR2
LBHD1
LCK
LCP2
LRRC7
LYN
MAP1B
MATK
MTMR1
MTMR10
MTMR2
MTMR6
MTMR8
MTMR9
MUC1
MUC4
MYCBP
MYCBP2
NCK1
NCK2
NDUFAB1
NEDD4
NRG1
NRG2
NSMCE1
ODF2L
PA2G4
PDGFRA
PFDN2
PFDN4
PHPT1
PIK3R1
PIK3R2
PIK3R3
PIN4
PLCG1
PLCG2
PPM1A
PPM1B
PPM1F
PPM1K
PPM1M
PRDX5
PRKACA
PRRG4
PSMA5
PTEN
PTGES3
PTK2
PTK2B
PTK6
PTPDC1
PTPN11
PTPN12
PTPN20
PTPN6
PTPN7
PTPRH
PTPRR
RALGAPA1
RASA1
RASA4
RGS4
RIN1
RNF41
RPN1
RTN4
RWDD2A
S100A10
SAP18
SELENOK
SF3B6
SH2B1
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3A
SH2D3C
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SHD
SLA
SLA2
SMIM20
SNAP91
SNRPB2
SOCS2
SOCS3
SOCS5
SOCS6
SOS1
SRC
SRPK2
STAP1
STYX
SYK
SYNM
TBCA
TCEA2
TEC
TMA7
TMEM134
TMEM14A
TMEM230
TNS1
TNS2
TNS3
TNS4
TPTE
TRIR
TVP23B
TXK
TXN
TXNL4A
VAV1
VAV2
VAV3
VTA1
WRNIP1
YES1
YWHAZ
ZAP70
ZNF207
ZNF532
350 interacting genes:
AATK
ABCB5
ABL1
ABL2
ACP1
ACP3
ADGRB1
AIP
AKAP12
AKT1
ALDOA
ALDOC
ALK
ANKS1A
ANKS1B
ANXA6
AP3B2
APBB1
APBB3
APLP1
ARF1
ARF5
ARNT
ASRGL1
ATP6AP1
ATP6V0C
AURKA
BAAT
BCAR3
BECN1
BLK
BLNK
BMX
BNIP1
BTC
CACYBP
CALM1
CAV1
CBLC
CBR1
CCDC180
CCND2
CCT3
CD44
CD82
CDK4
CDK6
CDK8
CDKN2B
CDKN2C
CEND1
CFAP298
CFL1
CHN1
CISH
CKB
CLASP2
CLCN6
CLNK
COL9A2
COL9A3
CRIP2
CRK
CRKL
CSDE1
CTNNB1
CXCL8
CYLC2
CYP17A1
DAB1
DDR1
DLG4
DOK1
DOK4
DOK6
DST
DUSP14
DUSP18
DUSP19
EGF
EGFR
EPHA1
EPHA2
EPHA3
EPHA4
EPHA5
EPHB1
EPHB2
EPHB3
EPHB6
ERBB3
ERBB4
ERBIN
ERG28
ERRFI1
ESR1
FAM241B
FBP1
FBXO7
FER
FES
FGFR1
FGFR2
FGFR3
FGFR4
FGR
FKBP1A
FKBP3
FKBP8
FLNB
FLT3
FLT4
FRAT2
FZR1
GAB1
GABARAPL1
GABARAPL2
GAPDH
GLCE
GLIS2
GLRX3
GMPR2
GPM6B
GRAP2
GRB10
GRB14
GRB2
GRB7
GRK2
GRM1
GSN
HCK
HDAC6
HDLBP
HGF
HLA-A
HRAS
HSD17B3
HSH2D
HSP90AA1
HSP90B1
HSPA1A
HSPA5
HSPA9
HSPD1
IARS1
IGF1R
IL13RA2
IL6ST
ILF3
ILKAP
INPPL1
INSR
INSRR
IRF2BP2
IRS1
IRS4
ITGA5
ITGB4
ITK
ITPKA
ITPR1
JAK1
JAK2
JMJD4
JUP
KCTD6
KDELR2
KLC1
KLK5
LATS2
LCK
LCP2
LGALS8
LPCAT4
LRRC7
LYN
LYPD3
MAP2K1
MAP2K3
MAP2K5
MAPK8IP1
MAPK8IP2
MATK
MDH1
MEPCE
MERTK
MET
MSN
MST1R
MTCH1
MUC1
MUC4
MUCL1
MYC
MYO9A
NAT2
NCK1
NCK2
NEFH
NF2
NINL
NRG1
NTRK1
NTRK2
NTRK3
NUDT16L1
ODF2L
PABPC1
PAK1
PDCD11
PDGFRA
PDGFRB
PEBP1
PGAM1
PHF23
PICK1
PIK3C2A
PIK3C2B
PIK3R1
PIK3R2
PIK3R3
PIN4
PLCG1
PLCG2
POLD2
POU6F1
PPA1
PPM1A
PPM1F
PRDM14
PRDX5
PSAP
PSMA1
PSMC3
PSMC3IP
PSMD3
PTGES3L-AARSD1
PTK2
PTK2B
PTK6
PTK7
PTPN11
PTPN18
PTPN6
PTPRR
PTPRT
PTPRU
RAB5C
RAF1
RASA1
RASSF1
RBM15B
RET
RHBDD2
RHOBTB2
RIN1
RIN2
ROR2
RPRML
RTN4
S100A11
SAFB2
SELENOK
SERPINA3
SFRP4
SH2B1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3A
SH2D3C
SH2D5
SH3BGRL3
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SHD
SLA
SLA2
SLC7A4
SMAD1
SMIM20
SMPD4
SNAP91
SOCS1
SOCS3
SOCS5
SOCS6
SOS1
SPP1
SRC
SRPK1
STAP1
STAT3
STIP1
STK11
STK24
STMN1
STMN2
STUB1
STYK1
STYX
SUPT6H
SYK
SYNM
TCEAL2
TEC
TGFA
TGFB1
THRSP
TLN1
TMA7
TMEM134
TMEM230
TNS1
TNS2
TNS3
TOB1
TP53
TRIP6
TRMO
TSEN15
TTC9B
TTYH2
TVP23B
TXK
TXN
TYMP
TYRO3
UBB
USP2
UTP18
VAPA
VAV1
VAV2
VAV3
YES1
YWHAZ
ZAP70
ZFAND1
ZMAT2
ZMYND8
ZNF189
ZNF532
Entrez ID
2065
2064
HPRD ID
01820
01281
Ensembl ID
ENSG00000065361
ENSG00000141736
Uniprot IDs
P21860
F5H1T4
J3QLU9
P04626
X5DNK3
PDB IDs
1M6B
2L9U
3KEX
3LMG
3P11
4LEO
4P59
4RIW
4RIX
4RIY
5CUS
5O4O
5O7P
6KBI
6OP9
1MFG
1MFL
1MW4
1N8Z
1OVC
1QR1
1S78
2A91
2JWA
2KS1
2L4K
2N2A
3BE1
3H3B
3MZW
3N85
3PP0
3RCD
3WLW
3WSQ
4GFU
4HRL
4HRM
4HRN
5K33
5KWG
5MY6
5O4G
5OB4
5TQS
6ATT
6BGT
6J71
6OGE
Enriched GO Terms of Interacting Partners
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