LYN and PIK3CG

Data Source:
HPRD (in vivo)

		LYN	PIK3CG
Description		LYN proto-oncogene, Src family tyrosine kinase	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Intermembrane Space Golgi Apparatus Cytosol Plasma Membrane Adherens Junction Postsynaptic Density Mitochondrial Crista Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Integrin Alpha2-beta1 Complex Intracellular Membrane-bounded Organelle Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Complex, Class IB Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding ATP Binding Kinase Activity SH3 Domain Binding Ubiquitin Protein Ligase Binding Gamma-tubulin Binding Glycosphingolipid Binding Ion Channel Binding Ephrin Receptor Binding Phosphoprotein Binding Phosphorylation-dependent Protein Binding	Protein Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Identical Protein Binding Ephrin Receptor Binding Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol Kinase Activity Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	B Cell Homeostasis Regulation Of Cytokine Production Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Tolerance Induction To Self Antigen Histamine Secretion By Mast Cell Platelet Degranulation Negative Regulation Of Myeloid Leukocyte Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Regulation Of B Cell Apoptotic Process Protein Phosphorylation Cellular Response To DNA Damage Stimulus Response To Sterol Depletion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Toxic Substance Response To Hormone Response To Carbohydrate Positive Regulation Of Neuron Projection Development Oligodendrocyte Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Organic Cyclic Compound Viral Process Peptidyl-tyrosine Phosphorylation Cell Differentiation Platelet Activation Erythrocyte Differentiation Positive Regulation Of Cell Migration Negative Regulation Of B Cell Proliferation Neuron Projection Development T Cell Costimulation Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Extracellular Stimulus Response To Insulin Regulation Of Mast Cell Activation Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Heat Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Response To Amino Acid Regulation Of Mast Cell Degranulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Erythrocyte Differentiation Positive Regulation Of Ras Protein Signal Transduction Protein Autophosphorylation Ephrin Receptor Signaling Pathway Response To Axon Injury Regulation Of Inflammatory Response Negative Regulation Of Immune Response B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Cellular Component Movement Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Cellular Response To Retinoic Acid Regulation Of Monocyte Chemotaxis Regulation Of Platelet Aggregation Dendritic Cell Differentiation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Dendritic Cell Apoptotic Process	Angiogenesis Cytokine Production Adaptive Immune Response Dendritic Cell Chemotaxis Positive Regulation Of Acute Inflammatory Response Respiratory Burst Involved In Defense Response Sphingosine-1-phosphate Receptor Signaling Pathway Protein Phosphorylation Phosphatidylinositol Biosynthetic Process Endocytosis Inflammatory Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Endothelial Cell Migration T Cell Chemotaxis Negative Regulation Of Triglyceride Catabolic Process Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Phosphorylation Cell Migration Platelet Activation Neutrophil Chemotaxis Secretory Granule Localization Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Rac Protein Signal Transduction Natural Killer Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process T Cell Proliferation T Cell Activation Mast Cell Degranulation Positive Regulation Of MAP Kinase Activity Innate Immune Response Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Cardiac Muscle Contraction Platelet Aggregation Cellular Response To CAMP Neutrophil Extravasation Hepatocyte Apoptotic Process Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Fibroblast Apoptotic Process
Pathways		GPVI-mediated activation cascade Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Cell surface interactions at the vascular wall FCGR activation PECAM1 interactions Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling EPH-Ephrin signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation CD28 co-stimulation CTLA4 inhibitory signaling EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Dectin-2 family CD209 (DC-SIGN) signaling CD22 mediated BCR regulation Cyclin D associated events in G1 Platelet Adhesion to exposed collagen Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Growth hormone receptor signaling Growth hormone receptor signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	GPVI-mediated activation cascade Synthesis of PIPs at the plasma membrane G beta:gamma signalling through PI3Kgamma Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Drugs		Dasatinib 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Bosutinib Ponatinib Nintedanib Fostamatinib	Staurosporine Myricetin LY-294002 Quercetin 5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE XL765 TG100-115 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide 5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL (5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE Wortmannin 1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine Duvelisib Fostamatinib
Diseases
GWAS		Granulocyte count ( 27863252) Height ( 18391951) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Platelet count ( 32888494) Refractive error ( 32231278) Serum thyroid-stimulating hormone levels ( 24852370) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) White blood cell count ( 29403010 32888494 27863252)	Antisaccade task score ( 31596458) Blood pressure ( 21909110) Carotid intima media thickness ( 30510157 21909108) Carotid plaque ( 30510157) Mean platelet volume ( 22139419 24026423 19820697 22423221 28031487) Metabolite levels ( 23823483) Platelet aggregation ( 29185836) Platelet count ( 22139419 29066854 29403010 22423221) Pulse pressure ( 26390057 27841878 29403010 28739976 30487518) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 27841878 28739976) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		125 interacting genes: ACTB ADAM15 AR BANK1 BCAR1 BTK CASP3 CASP7 CASP9 CBL CBLC CD19 CD22 CD36 CD72 CD79A CD79B CDK1 CDK2 CDKN1B CHST15 COASY CREBBP CRKL CSF1R CSF2RA CSF2RB CSF3R CSK CSNK2B CTLA4 DAPP1 DLG4 DOK1 DOK2 DOK3 EGFR EPOR ERBB2 ERBB3 ERBB4 EVL FASLG FCAR FCER1G FCGR2A FCGR2B FOLR1 GAB1 GAB2 GAB3 GP6 GRIA3 HCLS1 HNRNPK IGHA1 IL1B IL2RB IL7R INPP5D ITPR1 JAK2 KHDRBS1 KIT LCP2 LIME1 MAP4K1 MAPK3 MATK MET MME MS4A1 MS4A2 MUC1 NDFIP2 NEDD9 NMT1 NPHS1 PAG1 PAK2 PDE4A PDE4D PECAM1 PIK3CG PILRB PLCG1 PLCG2 PPP1R15A PPP1R8 PRAM1 PRKCD PRKCQ PRKDC PTK2 PTK2B PTPN6 PTPRC RASA1 RGS16 RPL10 RPS6KB1 RPS6KB2 SH2B2 SHC1 SKAP1 SKAP2 SLC4A1 SNCA SPHK1 SPHK2 SRC STAT3 SYK TEC TNF TRAT1 TRIM28 TRIM55 TRIM63 TRIP10 TRPV4 TYK2 UBB UHRF2 UNC119	22 interacting genes: CD28 EPHA8 GAB1 GRB2 GRK2 GSN HRAS IL6ST KIT KRAS LYN NOTCH1 NRAS PIK3CD PIK3R5 PIK3R6 PTPN11 SEC14L2 SET SMPD2 TPM2 ZNF282
Entrez ID		4067	5294
HPRD ID		01301	03135
Ensembl ID		ENSG00000254087	ENSG00000105851
Uniprot IDs		A8K379 P07948 Q6NUK7	A0A024R720 A8K9G9 P48736
PDB IDs		1W1F 1WA7 3A4O 5XY1 6NMW	1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHW 2CHX 2CHZ 2V4L 3APC 3APD 3APF 3CSF 3CST 3DBS 3DPD 3ENE 3IBE 3L08 3L13 3L16 3L17 3L54 3LJ3 3MJW 3ML8 3ML9 3NZS 3NZU 3OAW 3P2B 3PRE 3PRZ 3PS6 3QAQ 3QAR 3QJZ 3QK0 3R7Q 3R7R 3S2A 3SD5 3T8M 3TJP 3TL5 3ZVV 3ZW3 4ANU 4ANV 4ANW 4ANX 4AOF 4DK5 4EZJ 4EZK 4EZL 4F1S 4FA6 4FAD 4FHJ 4FHK 4FJY 4FJZ 4FLH 4FUL 4G11 4GB9 4HLE 4HVB 4J6I 4KZ0 4KZC 4PS3 4PS7 4PS8 4URK 4WWN 4WWO 4WWP 4XX5 4XZ4 5EDS 5G2N 5G55 5JHA 5JHB 5KAE 5OQ4 5T23 6AUD 6C1S 6FH5 6GQ7 6T3B 6T3C 6XRL 6XRM
Enriched GO Terms of Interacting Partners?
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