LYN and INPP5D

  • Data Source:
  • BioGRID (affinity chromatography technology, pull down)
  • HPRD (in vivo, in vitro)

LYN

INPP5D

Description LYN proto-oncogene, Src family tyrosine kinase inositol polyphosphate-5-phosphatase D
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Allergic disease (asthma, hay fever or eczema) ( 29083406)
  • Alzheimer's disease (late onset) ( 30617256 24162737)
  • Alzheimer's disease or family history of Alzheimer's disease ( 30617256)
  • Contrast sensitivity ( 24152035)
  • Crohn's disease ( 22412388 23128233)
  • Eosinophil counts ( 32888494 27863252)
  • Eosinophil percentage of granulocytes ( 27863252)
  • Eosinophil percentage of white cells ( 32888494 27863252)
  • Family history of Alzheimer's disease ( 30617256)
  • High light scatter reticulocyte count ( 32888494)
  • High light scatter reticulocyte percentage of red cells ( 32888494)
  • Immature fraction of reticulocytes ( 32888494)
  • Neutrophil count ( 32888494)
  • Neutrophil percentage of granulocytes ( 27863252)
  • Perceived unattractiveness to mosquitoes ( 28199695)
  • Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
  • Sum eosinophil basophil counts ( 27863252)
Interacting Genes 125 interacting genes: ACTB ADAM15 AR BANK1 BCAR1 BTK CASP3 CASP7 CASP9 CBL CBLC CD19 CD22 CD36 CD72 CD79A CD79B CDK1 CDK2 CDKN1B CHST15 COASY CREBBP CRKL CSF1R CSF2RA CSF2RB CSF3R CSK CSNK2B CTLA4 DAPP1 DLG4 DOK1 DOK2 DOK3 EGFR EPOR ERBB2 ERBB3 ERBB4 EVL FASLG FCAR FCER1G FCGR2A FCGR2B FOLR1 GAB1 GAB2 GAB3 GP6 GRIA3 HCLS1 HNRNPK IGHA1 IL1B IL2RB IL7R INPP5D ITPR1 JAK2 KHDRBS1 KIT LCP2 LIME1 MAP4K1 MAPK3 MATK MET MME MS4A1 MS4A2 MUC1 NDFIP2 NEDD9 NMT1 NPHS1 PAG1 PAK2 PDE4A PDE4D PECAM1 PIK3CG PILRB PLCG1 PLCG2 PPP1R15A PPP1R8 PRAM1 PRKCD PRKCQ PRKDC PTK2 PTK2B PTPN6 PTPRC RASA1 RGS16 RPL10 RPS6KB1 RPS6KB2 SH2B2 SHC1 SKAP1 SKAP2 SLC4A1 SNCA SPHK1 SPHK2 SRC STAT3 SYK TEC TNF TRAT1 TRIM28 TRIM55 TRIM63 TRIP10 TRPV4 TYK2 UBB UHRF2 UNC119 45 interacting genes: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R CYSRT1 DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR1B FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP6-3 LILRB4 LYN MET NOTCH2NLA PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 SLAMF1 XIAP ZDHHC17
Entrez ID 4067 3635
HPRD ID 01301 09033
Ensembl ID ENSG00000254087 ENSG00000168918
Uniprot IDs A8K379 P07948 Q6NUK7 Q92835
PDB IDs 1W1F 1WA7 3A4O 5XY1 6NMW 2YSX 6IBD 6XY7
Enriched GO Terms of Interacting Partners?
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