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LYN and MET
Data Source:
BioGRID
(pull down)
LYN
MET
Description
LYN proto-oncogene, Src family tyrosine kinase
MET proto-oncogene, receptor tyrosine kinase
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrial Intermembrane Space
Golgi Apparatus
Cytosol
Plasma Membrane
Adherens Junction
Postsynaptic Density
Mitochondrial Crista
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Integrin Alpha2-beta1 Complex
Intracellular Membrane-bounded Organelle
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Postsynaptic Specialization, Intracellular Component
Extracellular Region
Plasma Membrane
Integral Component Of Plasma Membrane
Basal Plasma Membrane
Cell Surface
Integral Component Of Membrane
Receptor Complex
Molecular Function
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Kinase Activity
SH3 Domain Binding
Ubiquitin Protein Ligase Binding
Gamma-tubulin Binding
Glycosphingolipid Binding
Ion Channel Binding
Ephrin Receptor Binding
Phosphoprotein Binding
Phosphorylation-dependent Protein Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Hepatocyte Growth Factor-activated Receptor Activity
Protein Binding
ATP Binding
Semaphorin Receptor Activity
Protein Phosphatase Binding
Identical Protein Binding
Biological Process
B Cell Homeostasis
Regulation Of Cytokine Production
Regulation Of Protein Phosphorylation
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Fc Receptor Mediated Stimulatory Signaling Pathway
Tolerance Induction To Self Antigen
Histamine Secretion By Mast Cell
Platelet Degranulation
Negative Regulation Of Myeloid Leukocyte Differentiation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Fc Receptor Mediated Inhibitory Signaling Pathway
Regulation Of B Cell Apoptotic Process
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
Response To Sterol Depletion
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Blood Coagulation
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Toxic Substance
Response To Hormone
Response To Carbohydrate
Positive Regulation Of Neuron Projection Development
Oligodendrocyte Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Response To Organic Cyclic Compound
Viral Process
Peptidyl-tyrosine Phosphorylation
Cell Differentiation
Platelet Activation
Erythrocyte Differentiation
Positive Regulation Of Cell Migration
Negative Regulation Of B Cell Proliferation
Neuron Projection Development
T Cell Costimulation
Lipopolysaccharide-mediated Signaling Pathway
Cellular Response To Extracellular Stimulus
Response To Insulin
Regulation Of Mast Cell Activation
Regulation Of Cell Adhesion Mediated By Integrin
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Cellular Response To Heat
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Response To Drug
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Response To Amino Acid
Regulation Of Mast Cell Degranulation
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Regulation Of Erythrocyte Differentiation
Positive Regulation Of Ras Protein Signal Transduction
Protein Autophosphorylation
Ephrin Receptor Signaling Pathway
Response To Axon Injury
Regulation Of Inflammatory Response
Negative Regulation Of Immune Response
B Cell Receptor Signaling Pathway
Regulation Of B Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Cellular Component Movement
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Glial Cell Proliferation
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Oligodendrocyte Progenitor Proliferation
Negative Regulation Of Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Cellular Response To Retinoic Acid
Regulation Of Monocyte Chemotaxis
Regulation Of Platelet Aggregation
Dendritic Cell Differentiation
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Dendritic Cell Apoptotic Process
MAPK Cascade
Endothelial Cell Morphogenesis
Liver Development
Phagocytosis
Signal Transduction
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Nervous System Development
Negative Regulation Of Autophagy
Cell Migration
Peptidyl-tyrosine Phosphorylation
Neuron Differentiation
Pancreas Development
Positive Regulation Of Microtubule Polymerization
Positive Regulation Of Kinase Activity
Negative Regulation Of Rho Protein Signal Transduction
Entry Of Bacterium Into Host Cell
Positive Regulation Of Transcription By RNA Polymerase II
Hepatocyte Growth Factor Receptor Signaling Pathway
Branching Morphogenesis Of An Epithelial Tube
Positive Chemotaxis
Negative Regulation Of Stress Fiber Assembly
Positive Regulation Of Protein Kinase B Signaling
Establishment Of Skin Barrier
Negative Regulation Of Thrombin-activated Receptor Signaling Pathway
Semaphorin-plexin Signaling Pathway
Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity
Positive Regulation Of Endothelial Cell Chemotaxis
Pathways
GPVI-mediated activation cascade
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
Dectin-2 family
CD209 (DC-SIGN) signaling
CD22 mediated BCR regulation
Cyclin D associated events in G1
Platelet Adhesion to exposed collagen
Signaling by Erythropoietin
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Growth hormone receptor signaling
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Sema4D mediated inhibition of cell attachment and migration
RAF/MAP kinase cascade
MET Receptor Activation
Negative regulation of MET activity
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates RAS signaling
MET activates PI3K/AKT signaling
MET activates PTPN11
MET activates PTK2 signaling
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
MET interacts with TNS proteins
MET activates RAP1 and RAC1
MET receptor recycling
MET activates STAT3
MECP2 regulates neuronal receptors and channels
Drugs
Dasatinib
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Bosutinib
Ponatinib
Nintedanib
Fostamatinib
K-252a
SGX-523
1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide
N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide
2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide
N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide
3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol
AMG-208
1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE
Crizotinib
Cabozantinib
Capmatinib
Fostamatinib
Tivantinib
Brigatinib
Amuvatinib
Diseases
Renal cell carcinoma
Cholangiocarcinoma
Gastric cancer
GWAS
Granulocyte count (
27863252
)
Height (
18391951
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
27863252
)
Platelet count (
32888494
)
Refractive error (
32231278
)
Serum thyroid-stimulating hormone levels (
24852370
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systemic lupus erythematosus (
28714469
)
White blood cell count (
29403010
32888494
27863252
)
Blood protein levels (
30072576
)
Gamma glutamyl transferase levels (
29403010
)
HDL cholesterol levels (
28334899
)
Hematocrit (
28017375
)
Lung function (FEV1/FVC) (
30804560
)
Medication use (beta blocking agents) (
31015401
)
Multiple sclerosis (severity) (
19010793
)
PR segment (
24850809
)
Pulse pressure (
30578418
)
Resting heart rate (
29769521
27798624
)
Triglyceride levels (
28334899
)
Triglycerides (
24097068
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
125 interacting genes:
ACTB
ADAM15
AR
BANK1
BCAR1
BTK
CASP3
CASP7
CASP9
CBL
CBLC
CD19
CD22
CD36
CD72
CD79A
CD79B
CDK1
CDK2
CDKN1B
CHST15
COASY
CREBBP
CRKL
CSF1R
CSF2RA
CSF2RB
CSF3R
CSK
CSNK2B
CTLA4
DAPP1
DLG4
DOK1
DOK2
DOK3
EGFR
EPOR
ERBB2
ERBB3
ERBB4
EVL
FASLG
FCAR
FCER1G
FCGR2A
FCGR2B
FOLR1
GAB1
GAB2
GAB3
GP6
GRIA3
HCLS1
HNRNPK
IGHA1
IL1B
IL2RB
IL7R
INPP5D
ITPR1
JAK2
KHDRBS1
KIT
LCP2
LIME1
MAP4K1
MAPK3
MATK
MET
MME
MS4A1
MS4A2
MUC1
NDFIP2
NEDD9
NMT1
NPHS1
PAG1
PAK2
PDE4A
PDE4D
PECAM1
PIK3CG
PILRB
PLCG1
PLCG2
PPP1R15A
PPP1R8
PRAM1
PRKCD
PRKCQ
PRKDC
PTK2
PTK2B
PTPN6
PTPRC
RASA1
RGS16
RPL10
RPS6KB1
RPS6KB2
SH2B2
SHC1
SKAP1
SKAP2
SLC4A1
SNCA
SPHK1
SPHK2
SRC
STAT3
SYK
TEC
TNF
TRAT1
TRIM28
TRIM55
TRIM63
TRIP10
TRPV4
TYK2
UBB
UHRF2
UNC119
112 interacting genes:
ABL2
BAG1
BCAR3
BLK
BTK
CASP3
CBL
CCND2
CD44
CDK4
CDK6
CDKN2B
CNR1
CRK
CTNNB1
CTTN
DAPK3
DCN
DNAJA3
EGFR
EPHA2
ERBB2
FAS
FES
FGFR4
FGR
FZR1
GAB1
GLIS2
GLMN
GRB14
GRB2
GRB7
HCK
HGF
HGS
HSH2D
INPP5D
INPPL1
ITGB1
ITGB4
ITK
KDELR2
LATS2
LCK
LYN
MAP2K3
MAP2K5
MATK
MUC20
MYC
NCK1
NCK2
NF2
PCBD2
PIK3R1
PIK3R2
PIK3R3
PLCG1
PLCG2
PLXNB1
PTK6
PTPN11
PTPRB
PTPRJ
RAF1
RANBP10
RANBP9
RASA1
RASSF1
SH2B1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3C
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SHD
SLA2
SMC1A
SNAPIN
SNX2
SOCS1
SOCS2
SOCS3
SOCS5
SOCS6
SPSB1
SRC
STAP1
STAT3
STK11
SYK
TEC
TERT
TNS1
TNS2
TNS3
TNS4
TP53
TXK
VAV1
VAV2
VAV3
YES1
ZAP70
Entrez ID
4067
4233
HPRD ID
01301
01280
Ensembl ID
ENSG00000254087
ENSG00000105976
Uniprot IDs
A8K379
P07948
Q6NUK7
A0A024R728
A0A024R759
B4DLF5
E6Y365
P08581
PDB IDs
1W1F
1WA7
3A4O
5XY1
6NMW
1FYR
1R0P
1R1W
1SHY
1SSL
1UX3
2G15
2RFN
2RFS
2UZX
2UZY
2WD1
2WGJ
2WKM
3A4P
3BUX
3C1X
3CCN
3CD8
3CE3
3CTH
3CTJ
3DKC
3DKF
3DKG
3EFJ
3EFK
3F66
3F82
3I5N
3L8V
3LQ8
3Q6U
3Q6W
3QTI
3R7O
3RHK
3U6H
3U6I
3VW8
3ZBX
3ZC5
3ZCL
3ZXZ
3ZZE
4AOI
4AP7
4DEG
4DEH
4DEI
4EEV
4GG5
4GG7
4IWD
4K3J
4KNB
4MXC
4O3T
4O3U
4R1V
4R1Y
4XMO
4XYF
5DG5
5EOB
5EYC
5EYD
5HLW
5HNI
5HO6
5HOA
5HOR
5HTI
5LSP
5T3Q
5UAB
5UAD
5YA5
6GCU
6I04
6SD9
6SDC
6SDD
6SDE
6UBW
Enriched GO Terms of Interacting Partners
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