NLRP7 and STAMBP

Data Source:
BioGRID (enzymatic study)

		NLRP7	STAMBP
Description		NLR family pyrin domain containing 7	STAM binding protein
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GO Annotations	Cellular Component	Cellular_component	Nucleus Nucleoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Cleavage Furrow Extracellular Exosome
	Molecular Function	ATP Binding Aspartic-type Endopeptidase Inhibitor Activity Interleukin-1 Binding Caspase Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Protein Domain Specific Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity Isopeptidase Activity
	Biological Process	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Protein Processing Negative Regulation Of Interleukin-1 Beta Production Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Aspartic-type Peptidase Activity	Mitotic Cytokinesis Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Ras Protein Signal Transduction Protein K63-linked Deubiquitination
Pathways			Metalloprotease DUBs
Drugs
Diseases		Recurrent hydatidiform moles (RHM); Familial biparental hydatidiform
GWAS		Inflammatory bowel disease ( 23128233)	Anti-saccade response ( 29064472) Blood metabolite levels ( 26401656) Serum metabolite levels ( 23093944)
Interacting Genes		2 interacting genes: FAF1 STAMBP	45 interacting genes: ALAS1 AMN APOBEC3A BMPR1B CASR CHMP1A CHMP1B CHMP2A CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CLTC CTNNBL1 CYP2C9 EPS15 GRAP2 GRB2 IL1RL2 ITGA5 MAP2K5 MAP3K2 NLRP3 NLRP7 NTPCR PJA1 RECQL5 RNF11 SMAD2 SMAD6 SMAD7 SNCA SPG7 STAM STAM2 TNFRSF1A TP53 TRAF6 TRIP13 UACA UBC UBE2S USP21 USP28
Entrez ID		199713	10617
HPRD ID		10112	05877
Ensembl ID		ENSG00000167634	ENSG00000124356
Uniprot IDs		Q8WX94	A0A140VK54 O95630
PDB IDs		2KM6	2XZE 3RZU 3RZV 5IXF
Enriched GO Terms of Interacting Partners?
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