EIF2B1 and TRIM59

Data Source:
BioGRID (two hybrid)

		EIF2B1	TRIM59
Description		eukaryotic translation initiation factor 2B subunit alpha	tripartite motif containing 59
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Intraciliary Transport Particle B
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Translational Initiation Regulation Of Translational Initiation Response To Heat Response To Glucose Oligodendrocyte Development Response To Peptide Hormone Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway	Protein Ubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response
Pathways		Recycling of eIF2:GDP
Drugs
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Eosinophil percentage of white cells ( 32888494) Intrinsic epigenetic age acceleration ( 29374233) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		21 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D ATF5 BZW2 C1orf50 CREBBP EIF2B2 EIF2S1 EIF2S2 EPM2A GORASP2 MED29 MRPL4 NTAQ1 RD3 TRIM59 TRIML2 UBE2I	26 interacting genes: ANKRD33 BLZF1 CCDC33 CDK5 CLDN4 ECSIT EIF2B1 ESR1 ESR2 KRTAP13-3 MACROH2A1 MEI4 MRPL12 NECAB2 NRM PIN1 PLLP RASSF3 RHOU SEC22A SNAP47 UBE2J2 UBE2W VTI1B ZDHHC21 ZDHHC22
Entrez ID		1967	286827
HPRD ID		09458	15568
Ensembl ID		ENSG00000111361	ENSG00000213186
Uniprot IDs		Q14232	Q8IWR1
PDB IDs		3ECS 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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