TRIM59 and ZDHHC21

Data Source:
BioGRID (two hybrid)

		TRIM59	ZDHHC21
Description		tripartite motif containing 59	zinc finger DHHC-type palmitoyltransferase 21
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Intraciliary Transport Particle B	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Palmitoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity
	Biological Process	Protein Ubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response	Hair Follicle Development Regulation Of Vascular Associated Smooth Muscle Contraction Protein Targeting To Membrane Protein Phosphopantetheinylation Peptidyl-L-cysteine S-palmitoylation Protein Palmitoylation Sebaceous Gland Development Regulation Of Nitric-oxide Synthase Activity Adrenergic Receptor Signaling Pathway Regulation Of Establishment Of Endothelial Barrier Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell
Pathways			eNOS activation Extra-nuclear estrogen signaling
Drugs
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Eosinophil percentage of white cells ( 32888494) Intrinsic epigenetic age acceleration ( 29374233) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)	Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697) Hypothyroidism ( 22493691) Metabolite levels ( 23823483) Neuritic plaque ( 31497858) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		26 interacting genes: ANKRD33 BLZF1 CCDC33 CDK5 CLDN4 ECSIT EIF2B1 ESR1 ESR2 KRTAP13-3 MACROH2A1 MEI4 MRPL12 NECAB2 NRM PIN1 PLLP RASSF3 RHOU SEC22A SNAP47 UBE2J2 UBE2W VTI1B ZDHHC21 ZDHHC22	12 interacting genes: AQP6 CHODL CREB3 ELOVL4 ERGIC3 FAM210B MTERF3 MUC1 PGRMC2 RNASEK TMEM167B TRIM59
Entrez ID		286827	340481
HPRD ID		15568	15716
Ensembl ID		ENSG00000213186	ENSG00000175893
Uniprot IDs		Q8IWR1	Q8IVQ6
PDB IDs
Enriched GO Terms of Interacting Partners?
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