EIF2B1 and RD3

Data Source:
BioGRID (two hybrid, two hybrid)

		EIF2B1	RD3
Description		eukaryotic translation initiation factor 2B subunit alpha	RD3 regulator of GUCY2D
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Endosome Perinuclear Region Of Cytoplasm Cone Photoreceptor Outer Segment Rod Photoreceptor Outer Segment
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Translational Initiation Regulation Of Translational Initiation Response To Heat Response To Glucose Oligodendrocyte Development Response To Peptide Hormone Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway	Visual Perception Protein Transport Negative Regulation Of Guanylate Cyclase Activity Response To Stimulus Retina Development In Camera-type Eye
Pathways		Recycling of eIF2:GDP
Drugs
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)	Leber congenital amaurosis (LCR)
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Intelligence (MTAG) ( 29326435) Retinopathy in non-diabetics ( 23393555)
Interacting Genes		21 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D ATF5 BZW2 C1orf50 CREBBP EIF2B2 EIF2S1 EIF2S2 EPM2A GORASP2 MED29 MRPL4 NTAQ1 RD3 TRIM59 TRIML2 UBE2I	5 interacting genes: APP CABP2 EHMT2 EIF2B1 NTAQ1
Entrez ID		1967	343035
HPRD ID		09458	12726
Ensembl ID		ENSG00000111361	ENSG00000198570
Uniprot IDs		Q14232	Q7Z3Z2
PDB IDs		3ECS 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z	6DRF
Enriched GO Terms of Interacting Partners?
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