THAP12 and DNAJC3

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		THAP12	DNAJC3
Description		THAP domain containing 12	DnaJ heat shock protein family (Hsp40) member C3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Cytosol Membrane Azurophil Granule Lumen Extracellular Exosome Extracellular Vesicle
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding Protein Dimerization Activity	Protein Kinase Inhibitor Activity Protein Kinase Binding Chaperone Binding Misfolded Protein Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation	Negative Regulation Of Protein Kinase Activity Protein Folding In Endoplasmic Reticulum Positive Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Defense Response To Virus Cellular Response To Cold Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Pathways			Viral mRNA Translation XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433)	Body mass index ( 28552196)
Interacting Genes		10 interacting genes: DDX58 DNAJC3 EIF2AK2 EIF2S1 KIAA1958 MAPKAPK3 STK4 TACC1 TP53 ZNF526	7 interacting genes: DNAJB1 EIF2AK2 EIF2AK3 HSPA1A HSPA5 THAP12 TIRAP
Entrez ID		5612	5611
HPRD ID		09567	03114
Ensembl ID		ENSG00000137492	ENSG00000102580
Uniprot IDs		A0A140VJQ7 O43422	A8KA82 Q13217
PDB IDs			2Y4T 2Y4U
Enriched GO Terms of Interacting Partners?
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