VAC14 and GALT

Data Source:
BioGRID (two hybrid)

		VAC14	GALT
Description		VAC14 component of PIKFYVE complex	galactose-1-phosphate uridylyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extrinsic Component Of Vacuolar Membrane Endoplasmic Reticulum Cytosol Endosome Membrane Early Endosome Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle PAS Complex	Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Protein Binding Signaling Receptor Activity Identical Protein Binding	Protein Binding UDP-glucose:hexose-1-phosphate Uridylyltransferase Activity Zinc Ion Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Signal Transduction Viral Process Positive Regulation Of Kinase Activity	UDP-glucose Metabolic Process Galactose Metabolic Process UDP-glucose Catabolic Process Galactose Catabolic Process Galactose Catabolic Process Via UDP-galactose
Pathways		Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane	Defective GALT can cause Galactosemia Galactose catabolism
Drugs
Diseases			Galactosemia
GWAS		Diffuse cutaneous systemic sclerosis ( 29293537) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) High density lipoprotein cholesterol levels ( 28548082) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061) Pulse pressure ( 28135244)
Interacting Genes		107 interacting genes: ABHD11 ACSS1 AMT APP ARID5A ASB13 BCL2L1 BHLHE40 C11orf54 C19orf54 C2CD6 C4orf33 CASP1 CCDC103 CD209 CDRT4 CNTN2 COL8A1 CRK CRYBA1 CRYBA2 DDAH2 EEF1AKMT3 EHHADH EIF2S1 EIF6 FAM50B FIG4 FNDC3B GABPB2 GALT GINS3 GLIS2 GNB1 GTF3C2 HDHD3 HNF1B HNRNPLL INTS11 JMJD7 KHDC1 KRT82 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LINC00518 LPAL2 MBLAC1 MEOX2 METTL15 MGAT5B MPPED2 MTMR9 MVP MYOZ1 NDUFAB1 NGB NOS1 NTAQ1 OIT3 OTOS PBLD PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PPP6C PRADC1 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX2 RHBDL1 RHOXF2 RIPPLY1 RNASEH2C RSKR SIGLEC5 SMUG1 SNF8 SPRYD7 SRPK2 TCEANC TEX37 TP53BP1 TRIM55 TRIM63 UFSP1 VENTX VHLL WDR83 WRAP53 ZBTB49 ZCWPW1 ZNF34 ZNF720	7 interacting genes: GRPEL1 KRTAP6-2 NQO1 TNK2 TRIP13 UBTD2 VAC14
Entrez ID		55697	2592
HPRD ID		07660	06106
Ensembl ID		ENSG00000103043	ENSG00000213930
Uniprot IDs		Q08AM6	A0A0S2Z3Y7 B2RAT6 P07902
PDB IDs			1R3A 5IN3 6GQD
Enriched GO Terms of Interacting Partners?
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