PPP1R15A and PPP1R1A

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PPP1R15A	PPP1R1A
Description		protein phosphatase 1 regulatory subunit 15A	protein phosphatase 1 regulatory inhibitor subunit 1A
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane	Extracellular Space Cytoplasm
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity Protein Kinase Binding Protein Phosphatase Activator Activity	Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding
	Biological Process	Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Positive Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Endoplasmic Reticulum Stress Negative Regulation Of Protein Dephosphorylation Regulation Of Translational Initiation By EIF2 Alpha Dephosphorylation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein Localization To Endoplasmic Reticulum Positive Regulation Of Peptidyl-serine Dephosphorylation Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Dephosphorylation	Glycogen Metabolic Process Negative Regulation Of Phosphoprotein Phosphatase Activity Intracellular Signal Transduction
Pathways		Downregulation of TGF-beta receptor signaling Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Body fat mass ( 28552196) Hip circumference ( 28552196) Waist circumference ( 28552196)
Interacting Genes		16 interacting genes: BAG1 BCAR1 CTBP2 EIF2S1 HABP4 HSPA1A KIF3A KMT2A LYN POU3F3 PPP1CA PPP1R1A RAD21 SMARCB1 TSN ZNF512B	1 interacting genes: PPP1R15A
Entrez ID		23645	5502
HPRD ID		06572	17893
Ensembl ID		ENSG00000087074	ENSG00000135447
Uniprot IDs		O75807	Q13522
PDB IDs		4XPN
Enriched GO Terms of Interacting Partners?
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