EEF1A1 and RAB27A

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EEF1A1	RAB27A
Description		eukaryotic translation elongation factor 1 alpha 1	RAB27A, member RAS oncogene family
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Eukaryotic Translation Elongation Factor 1 Complex Plasma Membrane Membrane Cortical Actin Cytoskeleton Ruffle Membrane Secretory Granule Lumen Extracellular Exosome Cytoplasmic Side Of Lysosomal Membrane Ficolin-1-rich Granule Lumen	Photoreceptor Outer Segment Extracellular Region Lysosome Late Endosome Golgi Apparatus Cytosol Apical Plasma Membrane Secretory Granule Dendrite Secretory Granule Membrane Multivesicular Body Membrane Weibel-Palade Body Melanosome Membrane Specific Granule Lumen Melanosome Extracellular Exosome Exocytic Vesicle
	Molecular Function	TRNA Binding RNA Binding Translation Elongation Factor Activity GTPase Activity Protein Binding Calmodulin Binding GTP Binding Kinase Binding Protein Kinase Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Translation Translational Elongation Neutrophil Degranulation Cellular Response To Epidermal Growth Factor Stimulus Regulation Of D-erythro-sphingosine Kinase Activity Regulation Of Chaperone-mediated Autophagy	Protein Targeting Exocytosis Blood Coagulation Positive Regulation Of Gene Expression Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Multivesicular Body Organization Neutrophil Degranulation Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion
Pathways		Eukaryotic Translation Elongation Eukaryotic Translation Elongation Peptide chain elongation HSF1 activation Neutrophil degranulation Protein methylation Chaperone Mediated Autophagy	Insulin processing Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		Zinc Guanosine-5'-Diphosphate Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS			Fractional exhaled nitric oxide levels ( 25431337) Glioma ( 30714141)
Interacting Genes		130 interacting genes: ABTB2 ACTB ALPL ANKRD24 ANXA7 APLP1 AQP2 ARIH2 AXIN1 BBS1 BBS2 BBS4 BRMS1 BTBD2 CASP2 CCDC130 CCL18 CDC25A CDKN1A CKS2 COX17 CRADD CRCT1 CSRP2 DARS1 DIABLO DLEU1 DUSP7 DYNLL1 DYSF EIF3F EP300 EXOSC4 FAS GADD45A GADD45G HSPB2 HSPE1 HTRA2 IKBKG IMMT ITGB1BP1 ITSN1 KCNE3 KIF1B LAMA4 LAMTOR1 LAMTOR5 LSM3 MAD2L1BP MAGED2 MAP3K14 MAPK14 MLLT3 MNAT1 MRM1 MRPL42 MTRNR2L1 MYOC NEU1 NRAS NREP ORMDL3 PABPC4 PAEP PAFAH1B3 PAPSS1 PCDHA4 PFN2 PHYHIP PKN2 PLAUR PLCG1 POLE2 POLR2C PQBP1 PRKCD PSG9 PSMD11 PTPN4 PTPRCAP PTPRF RAB27A RAP2A RBBP8 RFC5 RGS12 RND1 RNF10 RPA2 RPLP1 RRAS RSRC1 SARS2 SDHAF2 SERPINB5 SERPINB9 SFN SHBG SMAD2 SMAD4 SMN1 SNCA SPP1 SSR1 STAT6 STMN2 SULT1E1 SUMO2 TAF9 TGIF1 TK1 TMPRSS3 TNFSF11 TP53BP2 TPT1 TRDMT1 TSPY1 TSPYL2 TTLL12 TTR UBQLN4 WARS1 XPO5 XRN2 YWHAG ZBTB16 ZCCHC10 ZNF24 ZPR1	28 interacting genes: ADRB2 APP CEP126 COPS6 EEF1A1 ERG28 EXPH5 GDF9 GDI1 GZMB LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16
Entrez ID		1915	5873
HPRD ID		00559	04845
Ensembl ID		ENSG00000156508	ENSG00000069974
Uniprot IDs		P68104 Q6IPS9	A2RU94 P51159
PDB IDs		1SYW 3C5J 6ZMO	6HUF
Enriched GO Terms of Interacting Partners?
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