MAP2K2 and ZNF207

Data Source:
BioGRID (two hybrid)

		MAP2K2	ZNF207
Description		mitogen-activated protein kinase kinase 2	zinc finger protein 207
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Mitochondrion Early Endosome Late Endosome Peroxisomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule Cell-cell Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm	Kinetochore Condensed Chromosome Kinetochore Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Microtubule Spindle Matrix
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding PDZ Domain Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Scaffold Protein Binding	DNA Binding RNA Binding Protein Binding Microtubule Binding Metal Ion Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Negative Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Regulation Of Stress-activated MAPK Cascade Peptidyl-serine Autophosphorylation Positive Regulation Of Transcription, DNA-templated ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Early Endosome To Late Endosome Transport	Mitotic Sister Chromatid Segregation Microtubule Bundle Formation Mitotic Spindle Assembly Checkpoint Attachment Of Spindle Microtubules To Kinetochore Microtubule Polymerization Protein Stabilization Cell Division Regulation Of Chromosome Segregation Mitotic Spindle Assembly
Pathways		MAPK1 (ERK2) activation Frs2-mediated activation Signal transduction by L1 Uptake and function of anthrax toxins RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by RAF1 mutants
Drugs		Bosutinib Trametinib Selumetinib Binimetinib Fostamatinib
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Eosinophil counts ( 32888494) Heel bone mineral density ( 30598549) Height ( 29782485) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Pulse pressure ( 30224653) White blood cell count ( 32888494)	Survival in pancreatic cancer ( 28470677)
Interacting Genes		20 interacting genes: ARAF BRAF CASP9 CCNDBP1 CNKSR1 COPS5 DUSP3 GRIN1 GRIN2D HNRNPK LAMTOR3 LIG4 MAPK1 MAPK3 MAPK8 MOS RAF1 RGS12 RIPOR2 ZNF207	9 interacting genes: ERBB3 HNRNPM HNRNPUL1 MAP2K2 POLR1B TET2 UBR5 WBP4 WDR77
Entrez ID		5605	7756
HPRD ID		03164	04576
Ensembl ID		ENSG00000126934	ENSG00000010244
Uniprot IDs		P36507	O43670
PDB IDs		1S9I 4H3Q
Enriched GO Terms of Interacting Partners?
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