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MAPK3 and ETS1
Data Source:
HPRD
(in vitro)
MAPK3
ETS1
Description
mitogen-activated protein kinase 3
ETS proto-oncogene 1, transcription factor
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Mitochondrion
Early Endosome
Late Endosome
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Caveola
Focal Adhesion
Pseudopodium
Protein-containing Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
Phosphotyrosine Residue Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
Phosphatase Binding
Identical Protein Binding
Scaffold Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Histone Acetyltransferase Binding
Identical Protein Binding
Biological Process
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Positive Regulation Of Protein Phosphorylation
Transcription Initiation From RNA Polymerase I Promoter
Protein Phosphorylation
Apoptotic Process
DNA Damage Induced Protein Phosphorylation
Cell Cycle
Cell Surface Receptor Signaling Pathway
Axon Guidance
Aging
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Toxic Substance
Positive Regulation Of Gene Expression
Positive Regulation Of Macrophage Chemotaxis
Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Phosphorylation
Peptidyl-serine Phosphorylation
Sensory Perception Of Pain
Arachidonic Acid Metabolic Process
Platelet Activation
Regulation Of Ossification
BMP Signaling Pathway
Regulation Of Cellular PH
Thyroid Gland Development
Positive Regulation Of Cyclase Activity
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Histone Phosphorylation
Cellular Response To Amino Acid Starvation
Cellular Response To Reactive Oxygen Species
Positive Regulation Of Histone Acetylation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Outer Ear Morphogenesis
Response To Exogenous DsRNA
Positive Regulation Of Translation
Positive Regulation Of Transcription By RNA Polymerase II
Decidualization
Thymus Development
Regulation Of DNA-binding Transcription Factor Activity
Cartilage Development
Stress-activated MAPK Cascade
Regulation Of Cytoskeleton Organization
Positive Regulation Of Telomerase Activity
Bergmann Glial Cell Differentiation
Face Development
Lung Morphogenesis
Trachea Formation
Cardiac Neural Crest Cell Development Involved In Heart Development
Protein-containing Complex Assembly
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Interleukin-1-mediated Signaling Pathway
Response To Epidermal Growth Factor
Cellular Response To Mechanical Stimulus
Cellular Response To Cadmium Ion
Cellular Response To Tumor Necrosis Factor
Caveolin-mediated Endocytosis
Regulation Of Golgi Inheritance
Positive Regulation Of Macrophage Proliferation
Regulation Of Cellular Response To Heat
Cellular Response To Dopamine
Positive Regulation Of Telomere Capping
Positive Regulation Of Xenophagy
Regulation Of Early Endosome To Late Endosome Transport
Negative Regulation Of Apolipoprotein Binding
Response To Hypoxia
Regulation Of Transcription By RNA Polymerase II
Immune Response
Female Pregnancy
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Mechanical Stimulus
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Regulation Of Extracellular Matrix Disassembly
Hypothalamus Development
Pituitary Gland Development
Cell Differentiation
PML Body Organization
Response To Estradiol
Response To Laminar Fluid Shear Stress
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Estrous Cycle
Positive Regulation Of Erythrocyte Differentiation
Regulation Of Angiogenesis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Cell Motility
Positive Regulation Of Inflammatory Response
Positive Regulation Of Cellular Component Movement
Angiogenesis Involved In Wound Healing
Cellular Response To Hydrogen Peroxide
Response To Interleukin-1
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways
MAPK3 (ERK1) activation
RAF-independent MAPK1/3 activation
ISG15 antiviral mechanism
Spry regulation of FGF signaling
Frs2-mediated activation
ERK/MAPK targets
ERK/MAPK targets
ERKs are inactivated
Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
RSK activation
Signal transduction by L1
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate NADPH Oxidases
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RNA Polymerase I Promoter Opening
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
ESR-mediated signaling
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Regulation of the apoptosome activity
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Suppression of apoptosis
Signaling downstream of RAS mutants
Signaling by MAP2K mutants
Signaling by RAF1 mutants
FCGR3A-mediated phagocytosis
Growth hormone receptor signaling
Oncogene Induced Senescence
Drugs
Sulindac
Acetylsalicylic acid
Minocycline
Arsenic trioxide
Purvalanol
5-iodotubercidin
Seliciclib
Cholecystokinin
Ulixertinib
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
30072576
)
Brain morphology (MOSTest) (
32665545
)
Childhood body mass index (
33045005
)
Hodgkin's lymphoma (
30194254
)
Multiple sclerosis (
31604244
24076602
)
Pubertal anthropometrics (
23449627
)
Schizophrenia (
28991256
25056061
29483656
)
Tonsillectomy (
27182965
28928442
)
Waist circumference (
28552196
)
Weight (
28552196
)
Adverse response to drug (
30420678
)
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
30929738
32296059
)
Asthma (childhood onset) (
30929738
)
Atopic dermatitis (
26482879
)
Celiac disease (
22057235
20190752
25920553
30572963
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Depressive and manic episodes in bipolar disorder (
26297903
)
Depressive episodes in bipolar disorder (
26297903
)
Eczema (
31361310
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Follicular lymphoma (
25279986
)
Glaucoma (
31959993
30054594
)
Glaucoma (multi-trait analysis) (
31959993
)
Granulocyte count (
27863252
)
Height (
31562340
)
Inflammatory bowel disease (
28067908
)
Intraocular pressure (
29617998
29785010
31959993
30054594
)
Itch intensity from mosquito bite (
28199695
)
Liver fibrosis in pediatric non-alcoholic fatty acid liver disease (
28918882
)
Lung function (FVC) (
30061609
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Manganese levels (
26025379
)
Medication use (thyroid preparations) (
31015401
)
Monocyte count (
32888494
27863252
)
Mosquito bite size (
28199695
)
Multiple sclerosis (
31604244
24076602
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
27863252
)
Neutrophil percentage of white cells (
32888494
)
Non-albumin protein levels (
29403010
)
Obesity-related traits (
23251661
)
Platelet count (
32888494
27863252
)
Plateletcrit (
32888494
27863252
)
Psoriasis (
25903422
23143594
)
Psoriasis vulgaris (
26626624
)
Refractive error (
32231278
)
Rheumatoid arthritis (
30423114
22446963
24390342
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Self-reported allergy (
23817569
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systemic lupus erythematosus (
27399966
23273568
26663301
26502338
20169177
28714469
19838193
)
Type 2 diabetes (
30054458
30297969
30718926
)
Ulcerative colitis (
28067908
)
White blood cell count (
32888494
27863252
)
Interacting Genes
186 interacting genes:
AKR1C1
AMOT
ARRB1
ATP1A1
AURKA
BCL2
BCL3
BRAF
BTBD10
BUB1
C1QBP
CASP8
CASP9
CAV1
CCDC6
CDC23
CDC25C
CDC45
CDH1
CDKN2A
CEBPB
CPXM1
CREBBP
CREM
CRP
CTNND1
CUEDC2
DAPK1
DCC
DCP1A
DLC1
DUSP1
DUSP10
DUSP3
DUSP4
DUSP5
DUSP6
DUSP9
EGFR
ELK1
ELK4
EPOR
ESR1
ETS1
ETV1
FBXW7
FCGR2B
FKBP2
FOS
FOXP2
FRS2
GAB1
GAB2
GATA1
GATA4
GJA1
GMFB
GRK2
GTF2I
HDAC4
HDAC6
HIF1A
HMMR
HNF4A
HSF1
HSF4
HSPB8
HTRA2
ID2
IER3
INSR
IRS1
ITGAV
ITGB3
JUN
JUND
KRT8
KSR2
L3MBTL3
LAMTOR3
LCK
LIPE
LRPAP1
LRRC4
LYN
MAFG
MAGEA11
MAGED1
MAP2K1
MAP2K2
MAP2K3
MAP3K14
MAPK14
MAPK8
MAPKAPK2
MAPT
MBP
MED1
METAP2
MKNK1
MYC
MYLK
MYOG
NAB2
NCKIPSD
NGFR
NRAS
NTRK1
NTRK3
NUP153
NUP58
PAK2
PDE6G
PDGFRL
PEA15
PFKM
PLAT
PLCB1
PPARA
PPP1CA
PPP2CA
PRKCD
PRKCE
PRKCZ
PTPN11
PTPN5
PTPN7
PTPRE
PTPRR
PXN
RAB4A
RAF1
RALGDS
RB1
RCAN1
RET
RNF114
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KB1
RPTOR
RXRA
SCAND1
SCRIB
SMAD2
SNCG
SORBS3
SOS1
SOX2
SP1
SPIB
SRC
SREBF1
SREBF2
STAR
STAT3
STAT5A
STK11
STMN1
STMN2
STUB1
SULT4A1
SYK
SYN1
SYNE2
TAL1
TAL2
TCF3
TGIF1
TH
TNFSF11
TOP2B
TP53
TRIM54
TSC2
TTYH3
UBE4B
UBTF
USP21
VDR
VPS52
ZC3HC1
ZNF219
ZNF7
50 interacting genes:
APLP2
APP
ARID4B
ARL6IP4
ATF2
BRCA1
CAMK2A
CAMK2B
COP1
CREBBP
CYBC1
DAXX
DNMT3L
EIF5B
EP300
ETS2
FOS
GATA3
HTATIP2
JUN
MAF
MAPK1
MAPK3
MAPK7
MED23
MEIS1
NCL
NCOR1
NFKB1
NR3C1
PARP1
PAX5
POU1F1
RBBP6
RPL13A
RUNX1T1
RUNX2
SMAD3
SP1
SP100
SPI1
SRA1
SRC
SRSF11
STAT5B
STAT6
TBP
TDP2
UBE2I
XRCC6
Entrez ID
5595
2113
HPRD ID
03479
01260
Ensembl ID
ENSG00000102882
ENSG00000134954
Uniprot IDs
L7RXH5
P27361
Q9BWJ1
A8K725
B4DW78
P14921
PDB IDs
2ZOQ
4QTB
6GES
1GVJ
2NNY
2STT
2STW
3MFK
3RI4
3WTS
3WTT
3WTU
3WTV
3WTW
3WTX
3WTY
3WTZ
3WU0
3WU1
4L0Y
4L0Z
4L18
4LG0
5ZMC
Enriched GO Terms of Interacting Partners
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