DUSP1 and HSPB2

Data Source:
BioGRID (two hybrid)

		DUSP1	HSPB2
Description		dual specificity phosphatase 1	heat shock protein family B (small) member 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Growth Factor Binding Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity
	Biological Process	Inactivation Of MAPK Activity Endoderm Formation Protein Dephosphorylation Negative Regulation Of Cell Adhesion Response To Light Stimulus Response To Estradiol Response To Retinoic Acid Cellular Response To Hormone Stimulus Response To Testosterone Peptidyl-tyrosine Dephosphorylation Intracellular Signal Transduction Peptidyl-threonine Dephosphorylation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Response To Glucocorticoid Negative Regulation Of Meiotic Cell Cycle Response To CAMP Response To Calcium Ion Peptidyl-serine Dephosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Mitotic Cell Cycle Arrest Negative Regulation Of Monocyte Chemotaxis Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of P38MAPK Cascade Cellular Response To Chemokine Negative Regulation Of DNA Biosynthetic Process	Response To Unfolded Protein Regulation Of Catalytic Activity
Pathways		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway
Drugs
Diseases
GWAS		C-reactive protein levels ( 30388399) Diastolic blood pressure ( 30224653) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Offspring birth weight ( 31043758) Optic cup area ( 28073927) Ulcerative colitis ( 26192919) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		14 interacting genes: AATK CKS1B HSPA4 HSPB2 MAPK1 MAPK12 MAPK14 MAPK3 MAPK8 MAPT POLR1H ROR2 SKP2 UBB	108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335
Entrez ID		1843	3316
HPRD ID		02835	03712
Ensembl ID		ENSG00000120129	ENSG00000170276
Uniprot IDs		B4DU40 P28562	A8KAH6 Q16082
PDB IDs		6APX 6D65 6D66 6D67	6F2R
Enriched GO Terms of Interacting Partners?
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