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DUSP1
Description
dual specificity phosphatase 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Protein Tyrosine/serine/threonine Phosphatase Activity
Protein Tyrosine/threonine Phosphatase Activity
MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
Growth Factor Binding
Mitogen-activated Protein Kinase Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Biological Process
Inactivation Of MAPK Activity
Endoderm Formation
Protein Dephosphorylation
Negative Regulation Of Cell Adhesion
Response To Light Stimulus
Response To Estradiol
Response To Retinoic Acid
Cellular Response To Hormone Stimulus
Response To Testosterone
Peptidyl-tyrosine Dephosphorylation
Intracellular Signal Transduction
Peptidyl-threonine Dephosphorylation
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of MAP Kinase Activity
Negative Regulation Of MAPK Cascade
Response To Glucocorticoid
Negative Regulation Of Meiotic Cell Cycle
Response To CAMP
Response To Calcium Ion
Peptidyl-serine Dephosphorylation
Negative Regulation Of ERK1 And ERK2 Cascade
Mitotic Cell Cycle Arrest
Negative Regulation Of Monocyte Chemotaxis
Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Negative Regulation Of P38MAPK Cascade
Cellular Response To Chemokine
Negative Regulation Of DNA Biosynthetic Process
Pathways
RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway
Drugs
Diseases
GWAS
C-reactive protein levels (
30388399
)
Diastolic blood pressure (
30224653
)
Inflammatory bowel disease (
26192919
)
Metabolite levels (
23823483
)
Offspring birth weight (
31043758
)
Optic cup area (
28073927
)
Ulcerative colitis (
26192919
)
Vertical cup-disc ratio (
31798171
25241763
28073927
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Interacting Genes
14 interacting genes:
AATK
CKS1B
HSPA4
HSPB2
MAPK1
MAPK12
MAPK14
MAPK3
MAPK8
MAPT
POLR1H
ROR2
SKP2
UBB
Entrez ID
1843
HPRD ID
02835
Ensembl ID
ENSG00000120129
Uniprot IDs
B4DU40
P28562
PDB IDs
6APX
6D65
6D66
6D67
Enriched GO Terms of Interacting Partners
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Tagcloud
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