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DRD3 and FLNA
Data Source:
HPRD
(in vivo, two hybrid)
DRD3
FLNA
Description
dopamine receptor D3
filamin A
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Endocytic Vesicle
Cell Projection
Apical Part Of Cell
Glutamatergic Synapse
GABA-ergic Synapse
Integral Component Of Postsynaptic Density Membrane
Extracellular Region
Nucleus
Nucleolus
Cytoplasm
Trans-Golgi Network
Cytosol
Actin Filament
Plasma Membrane
Brush Border
Cell-cell Junction
Focal Adhesion
Actin Cytoskeleton
Membrane
Z Disc
Cortical Cytoskeleton
Myb Complex
Actin Filament Bundle
Dendritic Shaft
Perikaryon
Axonal Growth Cone
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Apical Dendrite
Postsynapse
Glutamatergic Synapse
Molecular Function
Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go
G Protein-coupled Receptor Activity
Protein Binding
Protein Domain Specific Binding
D1 Dopamine Receptor Binding
G Protein-coupled Receptor Binding
RNA Binding
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
Potassium Channel Regulator Activity
Kinase Binding
Small GTPase Binding
Mu-type Opioid Receptor Binding
Fc-gamma Receptor I Complex Binding
Protein Homodimerization Activity
Ion Channel Binding
Cadherin Binding
SMAD Binding
Actin Filament Binding
GTPase Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Synaptic Transmission, Dopaminergic
G Protein-coupled Receptor Internalization
Cellular Calcium Ion Homeostasis
Autophagy
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Negative Regulation Of Adenylate Cyclase Activity
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Learning Or Memory
Learning
Locomotory Behavior
Positive Regulation Of Cell Population Proliferation
Visual Learning
Regulation Of Dopamine Secretion
Negative Regulation Of Sodium:proton Antiporter Activity
Positive Regulation Of Cytokinesis
Circadian Regulation Of Gene Expression
Response To Histamine
Social Behavior
Gastric Emptying
Positive Regulation Of Renal Sodium Excretion
Response To Cocaine
Dopamine Metabolic Process
Response To Drug
Negative Regulation Of Apoptotic Process
Regulation Of Potassium Ion Transport
Response To Morphine
Regulation Of Circadian Sleep/wake Cycle, Sleep
Response To Ethanol
Negative Regulation Of Blood Pressure
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription By RNA Polymerase II
Acid Secretion
Behavioral Response To Cocaine
Negative Regulation Of Oligodendrocyte Differentiation
Arachidonic Acid Secretion
Negative Regulation Of Protein Secretion
Musculoskeletal Movement, Spinal Reflex Action
Negative Regulation Of Cytosolic Calcium Ion Concentration
Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway
Regulation Of Dopamine Uptake Involved In Synaptic Transmission
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Synaptic Transmission, Glutamatergic
Prepulse Inhibition
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Positive Regulation Of Dopamine Receptor Signaling Pathway
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Regulation Of Locomotion Involved In Locomotory Behavior
Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Negative Regulation Of Voltage-gated Calcium Channel Activity
Angiogenesis
Epithelial To Mesenchymal Transition
Blood Vessel Remodeling
Platelet Degranulation
Heart Morphogenesis
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Negative Regulation Of Neuron Projection Development
Negative Regulation Of Transcription By RNA Polymerase I
Formation Of Radial Glial Scaffolds
Cerebral Cortex Development
Platelet Activation
Regulation Of Cell Migration
Actin Cytoskeleton Reorganization
Positive Regulation Of Actin Filament Bundle Assembly
Cell Junction Assembly
Protein Localization To Cell Surface
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Import Into Nucleus
MRNA Transcription By RNA Polymerase II
Negative Regulation Of Apoptotic Process
Receptor Clustering
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of DNA-binding Transcription Factor Activity
Wound Healing, Spreading Of Cells
Early Endosome To Late Endosome Transport
Establishment Of Protein Localization
Cell-cell Junction Organization
Positive Regulation Of Axon Regeneration
Synapse Organization
Protein Stabilization
Cytoplasmic Sequestering Of Protein
Defense Response To Virus
Actin Crosslink Formation
Cilium Assembly
Platelet Aggregation
Semaphorin-plexin Signaling Pathway
Protein Localization To Plasma Membrane
Tubulin Deacetylation
Mitotic Spindle Assembly
Establishment Of Sertoli Cell Barrier
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Potassium Ion Transmembrane Transport
Protein Localization To Bicellular Tight Junction
Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential
Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential
Positive Regulation Of Neural Precursor Cell Proliferation
Positive Regulation Of Integrin-mediated Signaling Pathway
Positive Regulation Of Neuron Migration
Pathways
Dopamine receptors
G alpha (i) signalling events
Platelet degranulation
GP1b-IX-V activation signalling
Cell-extracellular matrix interactions
RHO GTPases activate PAKs
OAS antiviral response
Drugs
Ziprasidone
Cabergoline
Ropinirole
Olanzapine
Clozapine
Sulpiride
Loxapine
Remoxipride
Pramipexole
Chlorpromazine
Buspirone
Haloperidol
Amoxapine
Lisuride
Apomorphine
Dopamine
Ergoloid mesylate
Pimozide
Domperidone
Pergolide
Bromocriptine
Quetiapine
Levodopa
Aripiprazole
Chlorprothixene
Paliperidone
Yohimbine
Methotrimeprazine
Iloperidone
Rotigotine
ACP-104
Cariprazine
Mianserin
Asenapine
Amisulpride
Sarizotan
Sumanirole
Captodiame
AS-8112
Blonanserin
Pipamperone
Tianeptine
Dihydro-alpha-ergocryptine
Epicriptine
Pardoprunox
Piribedil
Tiapride
Dihydroergocristine
Aripiprazole lauroxil
Artenimol
Diseases
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia
Periventricular nodular heterotopia (PVNH)
FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS
Chronotype (
30696823
)
Feeling hurt (
29500382
)
Personality dimensions (
23903073
)
Smooth-surface caries (
24556642
)
Immature fraction of reticulocytes (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
16 interacting genes:
CLIC6
DRD1
EEF1B2
EEF1G
EPB41
EPB41L1
EPB41L2
FLNA
GIPC1
GNAI1
GRB2
MPDZ
NCK1
NCS1
RDX
USP48
98 interacting genes:
ADAMTSL4
APC
AR
ARHGAP24
ARRB1
ARRB2
ASB2
BRCA1
BRCA2
CALCR
CAMK2G
CASR
CAV1
CCNB1
CDC42
CEACAM1
CMIP
DCN
DDIT4L
DRD1
DRD2
DRD3
DUX4
ERBB3
F3
FABP1
FBLIM1
FILIP1
FLNB
FURIN
GP1BA
GRIK1
GRIK3
GRM4
GRM5
GRM7
GRM8
HHLA3
HNRNPD
HSPA6
HSPB7
ITGB1
ITGB3
ITGB5
ITGB6
ITGB7
KCNE4
KCNJ2
KLHL12
LGALS14
LMNA
MAP2K4
MAPK14
MCPH1
MTDH
MTNR1A
MTNR1B
MYOT
MYOZ1
NLGN3
NPHP1
OPRM1
PAK1
PCBP2
PELO
PHOSPHO2
PLEKHF2
PRKCA
PSEN1
PSEN2
RAC1
RALA
REL
RFLNA
RHOA
SELE
SH2B3
SHBG
SIGLEC10
SIRPA
SMAD3
SMAD5
SPANXD
SRC
SUMO2
SVIL
SYNPO2
TCF4
TLR10
TNIP2
TP73
TRAF2
TRIM55
TRIO
TTN
USP19
VHL
YWHAG
Entrez ID
1814
2316
HPRD ID
00540
02060
Ensembl ID
ENSG00000151577
ENSG00000196924
Uniprot IDs
A1A4V4
A8K8E4
E9PCM4
P35462
X5D2G4
P21333
Q60FE5
Q6NXF2
PDB IDs
3PBL
2AAV
2BP3
2BRQ
2J3S
2JF1
2K3T
2K7P
2K7Q
2MTP
2W0P
2WFN
3CNK
3HOC
3HOP
3HOR
3ISW
3RGH
4M9P
4P3W
5XR1
6D8C
6EW1
Enriched GO Terms of Interacting Partners
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