PMF1 and SUGT1

Data Source:
BioGRID (pull down, affinity chromatography technology)

		PMF1	SUGT1
Description		polyamine modulated factor 1	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
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GO Annotations	Cellular Component	MIS12/MIND Type Complex Condensed Chromosome Kinetochore Nuclear MIS12/MIND Complex Nucleoplasm Transcription Regulator Complex Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle	Ubiquitin Ligase Complex Kinetochore Nucleus Cytosol Protein-containing Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Leucine Zipper Domain Binding	Protein Binding
	Biological Process	Transcription By RNA Polymerase II Cell Cycle Chromosome Segregation Positive Regulation Of Transcription, DNA-templated Cell Division	Mitotic Cell Cycle Regulation Of Protein Stability Positive Regulation By Host Of Symbiont Catalytic Activity Protein Stabilization
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 30604766) Intracerebral hemorrhage ( 24656865) Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Longevity (age >99th survival percentile) ( 31413261) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Stroke ( 29531354) White matter hyperintensity burden ( 25663218)
Interacting Genes		24 interacting genes: BICD2 CEP126 COPS6 COPS7A COPS7B CRMP1 DSN1 EFHC1 FBXO28 GDF9 GIT1 HSP90AA1 KDM1A MED31 MESD MIS12 NFE2L2 PTN SHC3 SUGT1 TBC1D21 TCP10L TSNAX USHBP1	17 interacting genes: BUB3 CSNK2A1 DSN1 HSP90AA1 HSPA4 MIS12 NR4A1 NSL1 PAXIP1 PHLPP1 PLK1 PMF1 PTGER4 S100A6 S100B S100P SKP1
Entrez ID		11243	10910
HPRD ID		11441	09160
Ensembl ID		ENSG00000160783	ENSG00000165416
Uniprot IDs		Q6P1K2	A8K7W3 B4DYC6 Q9Y2Z0
PDB IDs		5LSJ 5LSK	1RL1
Enriched GO Terms of Interacting Partners?
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