CYP27A1 and PRDX4

Data Source:
BioGRID (two hybrid)

		CYP27A1	PRDX4
Description		cytochrome P450 family 27 subfamily A member 1	peroxiredoxin 4
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Extracellular Region Nucleus Endoplasmic Reticulum Smooth Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Iron Ion Binding Steroid Hydroxylase Activity Heme Binding Vitamin D3 25-hydroxylase Activity Cholesterol 26-hydroxylase Activity Cholestanetriol 26-monooxygenase Activity	Protein Binding Thioredoxin Peroxidase Activity
	Biological Process	Bile Acid Biosynthetic Process Cholesterol Catabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Calcitriol Biosynthetic Process From Calciol	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Protein Maturation By Protein Folding Extracellular Matrix Organization Cellular Response To Stress Hydrogen Peroxide Catabolic Process Neutrophil Degranulation Cell Redox Homeostasis Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Endogenous sterols Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)	Neutrophil degranulation
Drugs
Diseases		Cerebrotendinous xanthomatosis; Van Bogaert-Scherer-Epstein Disease
GWAS		Diastolic blood pressure ( 30224653) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252) Male-pattern baldness ( 28196072) Reticulocyte count ( 27863252)
Interacting Genes		2 interacting genes: MTDH PRDX4	25 interacting genes: A1BG ALG12 APOB CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 PLG PRDX1 PRDX2 PRDX3 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN
Entrez ID		1593	10549
HPRD ID		05939	05935
Ensembl ID		ENSG00000135929	ENSG00000123131
Uniprot IDs		Q02318	Q13162 V9HW63
PDB IDs		1MFX	2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP
Enriched GO Terms of Interacting Partners?
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