CYP27A1

Description		cytochrome P450 family 27 subfamily A member 1
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Iron Ion Binding Steroid Hydroxylase Activity Heme Binding Vitamin D3 25-hydroxylase Activity Cholesterol 26-hydroxylase Activity Cholestanetriol 26-monooxygenase Activity
	Biological Process	Bile Acid Biosynthetic Process Cholesterol Catabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Calcitriol Biosynthetic Process From Calciol
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Endogenous sterols Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
Drugs
Diseases		Cerebrotendinous xanthomatosis; Van Bogaert-Scherer-Epstein Disease
GWAS		Diastolic blood pressure ( 30224653) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252) Male-pattern baldness ( 28196072) Reticulocyte count ( 27863252)
Novel Interacting Genes		1 novel interacting genes: DCP2
Interacting Genes		2 interacting genes: MTDH PRDX4
Entrez ID		1593
HPRD ID		05939
Ensembl ID		ENSG00000135929
Uniprot IDs		Q02318
PDB IDs		1MFX
Enriched GO Terms of Interacting Partners?
Tagcloud ?