VKORC1L1 and CISD2

Data Source:
BioGRID (two hybrid)

		VKORC1L1	CISD2
Description		vitamin K epoxide reductase complex subunit 1 like 1	CDGSH iron sulfur domain 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Protein-containing Complex Perinuclear Endoplasmic Reticulum
	Molecular Function	Protein Binding Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding	RNA Binding Protein Binding Protein Homodimerization Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Peptidyl-glutamic Acid Carboxylation Cellular Response To Oxidative Stress Vitamin K Metabolic Process	Autophagy Of Mitochondrion Multicellular Organism Aging Regulation Of Autophagy
Pathways		Metabolism of vitamin K
Drugs		Menadione
Diseases			Wolfram syndrome (WFS); DIDMOAD syndrome
GWAS		Calcium levels ( 24068962) Corneal structure ( 23291589) Estimated glomerular filtration rate ( 31152163) Intraocular pressure ( 30591961) Neutrophil count ( 32888494)	Asthma and attention deficit hyperactivity disorder ( 31619474) Estimated glomerular filtration rate ( 31152163) Primary biliary cholangitis ( 26394269) Schizophrenia ( 28991256) Type 2 diabetes ( 28869590)
Interacting Genes		11 interacting genes: AQP6 CISD2 ERGIC3 GORAB GPX8 MRM1 MS4A3 MTIF3 PCYT1A PCYT1B TMEM80	58 interacting genes: AIG1 APOL2 APP AQP10 BCL2L2 BET1 BMP10 BTN2A2 C14orf180 C2CD2L C4orf3 CDIPT CFHR5 CLDN10 CLN6 CYBC1 EHHADH EMD FAM241B GALNT15 GAST GPR37L1 HHATL IER3 KIR2DL3 LEPROTL1 LRP10 MAN2B2 MIP NAPB NRG4 NSG1 PGAP2 PLPP4 PLPPR2 PNKP POMGNT1 RTP2 RUSF1 SEC22A SERP2 SLC13A3 SLC35B4 SMIM1 SNORC SPP1 STX12 STX7 THSD7B TMEM187 TMEM243 TMEM43 TMEM86A TSPAN33 TTPA VAMP4 VKORC1L1 YIPF6
Entrez ID		154807	493856
HPRD ID		12312	17413
Ensembl ID		ENSG00000196715	ENSG00000145354
Uniprot IDs		A8K0F7 Q8N0U8	Q8N5K1
PDB IDs			3FNV 4OO7 4OOA
Enriched GO Terms of Interacting Partners?
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