SH3D19 and ADAM10

Data Source:
HPRD (in vivo)

		SH3D19	ADAM10
Description		SH3 domain containing 19	ADAM metallopeptidase domain 10
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Golgi-associated Vesicle Trans-Golgi Network Plasma Membrane Adherens Junction Focal Adhesion Synaptic Vesicle Cell Surface Postsynaptic Density Membrane Integral Component Of Membrane Clathrin-coated Vesicle Axon Specific Granule Membrane Neuronal Cell Body Dendritic Spine Intracellular Membrane-bounded Organelle Postsynaptic Membrane Pore Complex Extracellular Exosome Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum Synaptic Membrane Tetraspanin-enriched Microdomain Glutamatergic Synapse
	Molecular Function	Protein Binding	Endopeptidase Activity Metalloendopeptidase Activity Signaling Receptor Binding Integrin Binding Protein Binding Metallopeptidase Activity SH3 Domain Binding Protein Kinase Binding Protein Homodimerization Activity Metal Ion Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
	Biological Process	Cytoskeleton Organization Regulation Of Cell Morphogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis	In Utero Embryonic Development Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Spermatogenesis Positive Regulation Of Cell Population Proliferation Regulation Of Notch Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of T Cell Chemotaxis Protein Processing Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Amyloid-beta Formation Adherens Junction Organization Response To Tumor Necrosis Factor Notch Receptor Processing, Ligand-dependent Monocyte Activation Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Pore Complex Assembly Constitutive Protein Ectodomain Proteolysis Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Cell Cycle Arrest Cochlea Development Response To Antineoplastic Agent Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynapse Organization Regulation Of Vasculature Development Toxin Transport
Pathways		Golgi Associated Vesicle Biogenesis	Collagen degradation Degradation of the extracellular matrix Signaling by EGFR Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Neutrophil degranulation Post-translational protein phosphorylation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Amyloid fiber formation
Drugs			XL784
Diseases
GWAS			Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Apolipoprotein A1 levels ( 32203549) Chronotype ( 30696823) Diffusing capacity of carbon monoxide ( 30694715) Family history of Alzheimer's disease ( 30617256) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355) Metabolite levels ( 23823483) Schizophrenia ( 30285260)
Interacting Genes		12 interacting genes: ADAM10 ADAM12 ADAM15 ADAM17 ADAM9 CDC42 GRB2 SH3GL1 SH3GL3 SH3RF1 SH3YL1 SOS2	7 interacting genes: AXL DLL1 EFNA1 EFNA2 EPHA3 SH3D19 TGFA
Entrez ID		152503	102
HPRD ID		16364	03723
Ensembl ID		ENSG00000109686	ENSG00000137845
Uniprot IDs		A0A494C1M0 Q5HYK7	A0A024R5U5 O14672
PDB IDs			1M1I 6BDZ 6BE6
Enriched GO Terms of Interacting Partners?
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