SH3D19 and SOS2

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		SH3D19	SOS2
Description		SH3 domain containing 19	SOS Ras/Rho guanine nucleotide exchange factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane	Cytosol
	Molecular Function	Protein Binding	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Cytoskeleton Organization Regulation Of Cell Morphogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis	B Cell Homeostasis G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of T Cell Differentiation In Thymus Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Pro-B Cell Differentiation
Pathways		Golgi Associated Vesicle Biogenesis	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Activation of RAC1 Interleukin-15 signaling
Drugs
Diseases
GWAS			Birth weight ( 31043758) Erythema nodosum in inflammatory bowel disease ( 24487271) Estimated glomerular filtration rate ( 31015462) Hemoglobin ( 32888494) Intraocular pressure ( 29617998 29785010 31959993 30054594) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Periodontal disease-related phenotype (Socransky) ( 24347629) Pulse pressure ( 30578418) Red blood cell count ( 32888494)
Interacting Genes		12 interacting genes: ADAM10 ADAM12 ADAM15 ADAM17 ADAM9 CDC42 GRB2 SH3GL1 SH3GL3 SH3RF1 SH3YL1 SOS2	16 interacting genes: ABI1 ABL1 BIN1 CD2AP CRKL EGFR GRAP2 GRB2 HRAS ITSN2 PACSIN3 PLCG1 SH3D19 SHC1 SNX18 SNX9
Entrez ID		152503	6655
HPRD ID		16364	03149
Ensembl ID		ENSG00000109686	ENSG00000100485
Uniprot IDs		A0A494C1M0 Q5HYK7	Q07890
PDB IDs			6EIE
Enriched GO Terms of Interacting Partners?
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