ADAM10 and EPHA3

Data Source:
HPRD (in vitro)

		ADAM10	EPHA3
Description		ADAM metallopeptidase domain 10	EPH receptor A3
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Golgi-associated Vesicle Trans-Golgi Network Plasma Membrane Adherens Junction Focal Adhesion Synaptic Vesicle Cell Surface Postsynaptic Density Membrane Integral Component Of Membrane Clathrin-coated Vesicle Axon Specific Granule Membrane Neuronal Cell Body Dendritic Spine Intracellular Membrane-bounded Organelle Postsynaptic Membrane Pore Complex Extracellular Exosome Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum Synaptic Membrane Tetraspanin-enriched Microdomain Glutamatergic Synapse	Extracellular Region Nucleoplasm Early Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Actin Cytoskeleton Nuclear Membrane Neuron Projection Receptor Complex
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Signaling Receptor Binding Integrin Binding Protein Binding Metallopeptidase Activity SH3 Domain Binding Protein Kinase Binding Protein Homodimerization Activity Metal Ion Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding
	Biological Process	In Utero Embryonic Development Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Spermatogenesis Positive Regulation Of Cell Population Proliferation Regulation Of Notch Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of T Cell Chemotaxis Protein Processing Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Amyloid-beta Formation Adherens Junction Organization Response To Tumor Necrosis Factor Notch Receptor Processing, Ligand-dependent Monocyte Activation Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Pore Complex Assembly Constitutive Protein Ectodomain Proteolysis Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Cell Cycle Arrest Cochlea Development Response To Antineoplastic Agent Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynapse Organization Regulation Of Vasculature Development Toxin Transport	Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Kinase Activity Regulation Of GTPase Activity Negative Regulation Of Endocytosis Ephrin Receptor Signaling Pathway Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Retinoic Acid Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		Collagen degradation Degradation of the extracellular matrix Signaling by EGFR Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Neutrophil degranulation Post-translational protein phosphorylation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Amyloid fiber formation	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs		XL784	Fostamatinib
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Apolipoprotein A1 levels ( 32203549) Chronotype ( 30696823) Diffusing capacity of carbon monoxide ( 30694715) Family history of Alzheimer's disease ( 30617256) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355) Metabolite levels ( 23823483) Schizophrenia ( 30285260)	Adult body size ( 32376654) Atrial fibrillation ( 30061737 29892015) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Loneliness (multivariate analysis) ( 27629369) Lung function (FVC) ( 26635082) Orofacial clefts ( 22863734) Periodontitis (Mean PAL) ( 24024966) Post-bronchodilator FEV1 x air pollution (NO2) interaction in childhood asthma ( 31028280) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 27841878) Tea consumption ( 31046077) Thrombosis ( 26908601) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		7 interacting genes: AXL DLL1 EFNA1 EFNA2 EPHA3 SH3D19 TGFA	29 interacting genes: ABL1 ADAM10 CDKN2A CRK CTDSP2 DUSP18 DUSP21 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 ERBB2 FBXO7 FYN ILKAP MTMR11 PIM1 RBM18 RUFY1 RUFY2 SRC SRPK1 STAT3 STYX TP53 TPTE
Entrez ID		102	2042
HPRD ID		03723	01555
Ensembl ID		ENSG00000137845	ENSG00000044524
Uniprot IDs		A0A024R5U5 O14672	A0A140VJJ0 C9JXA2 P29320 Q6P4R6
PDB IDs		1M1I 6BDZ 6BE6	2GSF 2QO2 2QO7 2QO9 2QOB 2QOC 2QOD 2QOF 2QOI 2QOK 2QOL 2QON 2QOO 2QOQ 3DZQ 3FXX 3FY2 4G2F 4GK2 4GK3 4GK4 4L0P 4P4C 4P5Q 4P5Z 4TWN 4TWO 6IN0
Enriched GO Terms of Interacting Partners?
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