SH3D19 and ADAM9

Data Source:
HPRD (in vivo)

		SH3D19	ADAM9
Description		SH3 domain containing 19	ADAM metallopeptidase domain 9
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane	Extracellular Space Focal Adhesion Cell Surface Integral Component Of Membrane Intrinsic Component Of External Side Of Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Metalloendopeptidase Activity Protein Kinase C Binding Integrin Binding Protein Binding Collagen Binding Metallopeptidase Activity SH3 Domain Binding Laminin Binding Metal Ion Binding
	Biological Process	Cytoskeleton Organization Regulation Of Cell Morphogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis	Activation Of MAPKK Activity Membrane Protein Ectodomain Proteolysis Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Manganese Ion Cell Migration Keratinocyte Differentiation Positive Regulation Of Cell Migration Membrane Protein Intracellular Domain Proteolysis Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Macrophage Fusion Response To Tumor Necrosis Factor Monocyte Activation Response To Hydrogen Peroxide Positive Regulation Of Protein Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Response To Glucocorticoid Positive Regulation Of Keratinocyte Migration Response To Calcium Ion Cellular Response To Lipopolysaccharide
Pathways		Golgi Associated Vesicle Biogenesis	Collagen degradation
Drugs			INCB7839
Diseases			Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS			Basophil count ( 32888494)
Interacting Genes		12 interacting genes: ADAM10 ADAM12 ADAM15 ADAM17 ADAM9 CDC42 GRB2 SH3GL1 SH3GL3 SH3RF1 SH3YL1 SOS2	9 interacting genes: ITGA3 ITGA6 ITGAV MAD2L2 PRKCD SH3D19 SH3GLB1 SNX9 TNF
Entrez ID		152503	8754
HPRD ID		16364	04091
Ensembl ID		ENSG00000109686	ENSG00000168615
Uniprot IDs		A0A494C1M0 Q5HYK7	Q13443
PDB IDs			1M1V
Enriched GO Terms of Interacting Partners?
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