ADAM10 and EFNA2

Data Source:
HPRD (in vitro, in vivo)

		ADAM10	EFNA2
Description		ADAM metallopeptidase domain 10	ephrin A2
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Golgi-associated Vesicle Trans-Golgi Network Plasma Membrane Adherens Junction Focal Adhesion Synaptic Vesicle Cell Surface Postsynaptic Density Membrane Integral Component Of Membrane Clathrin-coated Vesicle Axon Specific Granule Membrane Neuronal Cell Body Dendritic Spine Intracellular Membrane-bounded Organelle Postsynaptic Membrane Pore Complex Extracellular Exosome Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum Synaptic Membrane Tetraspanin-enriched Microdomain Glutamatergic Synapse	Plasma Membrane Anchored Component Of Membrane Neuromuscular Junction Perikaryon
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Signaling Receptor Binding Integrin Binding Protein Binding Metallopeptidase Activity SH3 Domain Binding Protein Kinase Binding Protein Homodimerization Activity Metal Ion Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process	Protein Binding Ephrin Receptor Binding
	Biological Process	In Utero Embryonic Development Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Spermatogenesis Positive Regulation Of Cell Population Proliferation Regulation Of Notch Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of T Cell Chemotaxis Protein Processing Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Amyloid-beta Formation Adherens Junction Organization Response To Tumor Necrosis Factor Notch Receptor Processing, Ligand-dependent Monocyte Activation Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Pore Complex Assembly Constitutive Protein Ectodomain Proteolysis Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Cell Cycle Arrest Cochlea Development Response To Antineoplastic Agent Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynapse Organization Regulation Of Vasculature Development Toxin Transport	Cell-cell Signaling Axon Guidance Olfactory Bulb Development Osteoclast Differentiation Bone Remodeling Ephrin Receptor Signaling Pathway
Pathways		Collagen degradation Degradation of the extracellular matrix Signaling by EGFR Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Neutrophil degranulation Post-translational protein phosphorylation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Amyloid fiber formation	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs		XL784
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Apolipoprotein A1 levels ( 32203549) Chronotype ( 30696823) Diffusing capacity of carbon monoxide ( 30694715) Family history of Alzheimer's disease ( 30617256) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355) Metabolite levels ( 23823483) Schizophrenia ( 30285260)
Interacting Genes		7 interacting genes: AXL DLL1 EFNA1 EFNA2 EPHA3 SH3D19 TGFA	5 interacting genes: ADAM10 EPHA2 EPHA3 EPHA5 ZHX1
Entrez ID		102	1943
HPRD ID		03723	04132
Ensembl ID		ENSG00000137845	ENSG00000099617
Uniprot IDs		A0A024R5U5 O14672	O43921
PDB IDs		1M1I 6BDZ 6BE6	2WO3
Enriched GO Terms of Interacting Partners?
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