C1orf74 and WWTR1

Data Source:
BioGRID (two hybrid)

		C1orf74	WWTR1
Description		chromosome 1 open reading frame 74	WW domain containing transcription regulator 1
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane Nuclear Body
	Molecular Function	Protein Binding	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Tissue Homeostasis Negative Regulation Of Protein Phosphorylation Heart Process Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Stem Cell Division SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glomerulus Development Multicellular Organism Growth Hippo Signaling Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal Cell Differentiation Cilium Assembly Regulation Of SMAD Protein Signal Transduction Kidney Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus
Pathways			Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1- and WWTR1 (TAZ)-stimulated gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Physiological factors RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Alopecia areata ( 25608926)	Height ( 31562340) Polycystic ovary syndrome ( 32289280) Preeclampsia ( 23551011)
Interacting Genes		6 interacting genes: C22orf23 IGFBP6 MBD3L1 REL TEKT1 WWTR1	22 interacting genes: C1orf74 DAPK1 IL16 LATS1 LATS2 MFHAS1 NKX2-1 PAX3 PPP1CA RTN4IP1 RUNX1 SLC9A3R2 SUMO3 TCP11L1 TEAD1 TEAD2 TEAD3 TEAD4 WBP2 YWHAE YWHAG YWHAZ
Entrez ID		148304	25937
HPRD ID		08682	09580
Ensembl ID		ENSG00000162757	ENSG00000018408
Uniprot IDs		A0A0A8K8E6 Q96LT6	Q9GZV5
PDB IDs			5N5R 5N5T 5N5W 5N75 6RHC 6RJL 6RJQ 6RP6 6SLW 6SLX
Enriched GO Terms of Interacting Partners?
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