SLC13A1 and SEC61A1

Data Source:
BioGRID (protein complementation assay)

		SLC13A1	SEC61A1
Description		solute carrier family 13 member 1	SEC61 translocon subunit alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Sodium:sulfate Symporter Activity	Signal Sequence Binding Calcium Channel Activity Protein Binding Protein Transmembrane Transporter Activity Ribosome Binding
	Biological Process	Sodium Ion Transport Sulfate Transport Anion Transmembrane Transport Sulfate Transmembrane Transport	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Endoplasmic Reticulum Organization Posttranslational Protein Targeting To Membrane, Translocation Pronephric Nephron Development Protein Targeting To ER Calcium Ion Transmembrane Transport
Pathways		Sodium-coupled sulphate, di- and tri-carboxylate transporters	ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) High density lipoprotein cholesterol levels ( 30498476) Systolic blood pressure ( 30578418)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		31 interacting genes: ACOT2 ACTR10 APLP2 ARL6IP1 ASS1 CD59 COQ5 COQ9 CRYAB DYNLL1 FTL GRN HSPA1A MKRN1 NDUFS5 OGDHL PDZK1 PNPLA6 PRSS8 RHOA SDHD SEC61A1 SELPLG SERPINA1 SLC9A3R1 SLC9A3R2 TBRG1 TM4SF1 TMED10 TP53I11 TSPAN3	10 interacting genes: BAG6 CALM1 GET3 HSPA5 MLH1 PTEN SEC61G SERP1 SLC13A1 TNF
Entrez ID		6561	29927
HPRD ID		08394	15316
Ensembl ID		ENSG00000081800	ENSG00000058262
Uniprot IDs		A4D0X1 Q2NKK0 Q9BZW2	B3KME8 B3KNF6 P61619
PDB IDs			6W6L
Enriched GO Terms of Interacting Partners?
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