CPS1 and HSD17B10

Data Source:
BioGRID (two hybrid)

		CPS1	HSD17B10
Description		carbamoyl-phosphate synthase 1	hydroxysteroid 17-beta dehydrogenase 10
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GO Annotations	Cellular Component	Nucleolus Cytoplasm Mitochondrial Inner Membrane Mitochondrial Matrix Protein-containing Complex Mitochondrial Nucleoid	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex Mitochondrial Nucleoid
	Molecular Function	Carbamoyl-phosphate Synthase (ammonia) Activity Carbamoyl-phosphate Synthase (glutamine-hydrolyzing) Activity Endopeptidase Activity Calcium Ion Binding Protein Binding ATP Binding Phospholipid Binding Glutamate Binding Protein-containing Complex Binding Modified Amino Acid Binding	TRNA Binding RNA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Protein Binding Cholate 7-alpha-dehydrogenase Activity Testosterone Dehydrogenase [NAD(P)] Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
	Biological Process	Urea Cycle 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Proteolysis Glutamine Metabolic Process Nitrogen Compound Metabolic Process Midgut Development Response To Toxic Substance Response To Zinc Ion Response To Amine Citrulline Biosynthetic Process Triglyceride Catabolic Process Response To Food Response To Lipopolysaccharide Vasodilation Response To Drug Response To Starvation Response To Amino Acid Cellular Response To Fibroblast Growth Factor Stimulus Nitric Oxide Metabolic Process Homocysteine Metabolic Process Anion Homeostasis Response To Growth Hormone Hepatocyte Differentiation Carbamoyl Phosphate Biosynthetic Process Cellular Response To Ammonium Ion Cellular Response To CAMP Cellular Response To Glucagon Stimulus Cellular Response To Oleic Acid Response To Dexamethasone	Isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Mitochondrion Organization C21-steroid Hormone Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Branched-chain Amino Acid Catabolic Process Protein Homotetramerization Brexanolone Metabolic Process Mitochondrial TRNA Methylation Mitochondrial TRNA Processing Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing
Pathways		Urea cycle	tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion
Drugs		Carglumic acid	NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct Omega-3-carboxylic acids
Diseases		Carbamoyl phosphate synthetase I deficiency	2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Acylcarnitine levels ( 26068415) Alanine transaminase levels ( 29403010) Alzheimer's disease in APOE e4+ carriers ( 25778476) Amino acid levels ( 26068415) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Betaine levels in individuals undergoing cardiac evaluation ( 26822151) Blood metabolite levels ( 24816252) Blood urea nitrogen levels ( 31152163) Body mass index ( 26426971 25673413) Body mass index in asthmatics ( 23517042) Chronic kidney disease ( 31152163 26831199 20383146) Creatinine levels ( 31015462 29403010) Eosinophil counts ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fibrinogen ( 20031577 23969696) Fibrinogen levels ( 28107422 26561523) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glycine levels ( 31070104 30837465) HDL cholesterol ( 24097068) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Homocysteine levels ( 23824729 20154341) Lymphocyte counts ( 32888494) Macular telangiectasia type 2 ( 28250457) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 32888494 27863252) Metabolic traits ( 21886157) Metabolite levels ( 31628463 23378610) Metabolite levels (small molecules and protein measures) ( 27005778) Monocyte count ( 32888494) Neutrophil count ( 32888494) Non-small cell lung cancer ( 23144319) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma homocysteine levels (post-methionine load test) ( 24651765) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Positive urgency ( 30718321) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 31636271 24625756 25569235) Serum metabolite levels (CMS) ( 31636271) Serum uric acid levels ( 30993211) Systolic blood pressure ( 30224653) Urate levels ( 31578528) Urate levels in obese individuals ( 25811787) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolites ( 26352407) Urinary potassium to creatinine ratio ( 30910378) Urinary sodium to creatinine ratio ( 30910378) White blood cell count ( 32888494)	Bipolar disorder ( 31043756) Body mass index ( 28892062)
Interacting Genes		3 interacting genes: ARAF HSD17B10 RAF1	32 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CDC42 CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 MDH1 OGDH PDHA1 PDHB PDHX PRKN PTEN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1
Entrez ID		1373	3028
HPRD ID		01995	02223
Ensembl ID		ENSG00000021826	ENSG00000072506
Uniprot IDs		A0A024R454 P31327 Q6PEK7	A0A0S2Z410 Q99714
PDB IDs		2YVQ 4UTR 4UTV 4UTX 4UTZ 4UU7 4UU8 4UUA 4UUB 5DOT 5DOU 5OJO 6UEL	1F67 1SO8 1U7T 2O23
Enriched GO Terms of Interacting Partners?
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